ArticleJournal of neurophysiology2010
Tonotopic tuning in a sound localization circuit.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed.
- A comprehensive review of HCN channel expression and IJournal of neurophysiology · 2025Review
- Tonotopic differentiation of presynaptic neurotransmitter-releasing machinery in the auditory brainstem during the prehearing period and its selective deficits in Fmr1 knockout mice.The Journal of comparative neurology · 2022Article
- Cellular Strategies for Frequency-Dependent Computation of Interaural Time Difference.Frontiers in synaptic neuroscience · 2022Review
- Dendritic synapse geometry optimizes binaural computation in a sound localization circuit.Science advances · 2021Article
- Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.Frontiers in neural circuits · 2020Review
- Diversity of Axonal and Dendritic Contributions to Neuronal Output.Frontiers in cellular neuroscience · 2019Article
- Contribution of action potentials to the extracellular field potential in the nucleus laminaris of barn owl.Journal of neurophysiology · 2018Article
- Tonotopic Variation of the T-Type CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.HSOA trends in anatomy and physiology · 2018Article
- High-fidelity optical excitation of cortico-cortical projections at physiological frequencies.Journal of neurophysiology · 2016Article
- Metabotropic glutamate receptors in auditory processing.Neuroscience · 2014Review
- Neuronal specializations for the processing of interaural difference cues in the chick.Frontiers in neural circuits · 2014Review
- Theoretical foundations of the sound analog membrane potential that underlies coincidence detection in the barn owl.Frontiers in computational neuroscience · 2013Article
- Biophysical basis of the sound analog membrane potential that underlies coincidence detection in the barn owl.Frontiers in computational neuroscience · 2013Article
- Tonotopic organization of the hyperpolarization-activated current (Ih) in the mammalian medial superior olive.Frontiers in neural circuits · 2013Article
- Structural tuning and plasticity of the axon initial segment in auditory neurons.The Journal of physiology · 2012Review
- Signal-to-noise ratio in the membrane potential of the owl's auditory coincidence detectors.Journal of neurophysiology · 2012Article
- Adaptation of spike timing precision controls the sensitivity to interaural time difference in the avian auditory brainstem.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Control of neuronal excitability by NMDA-type glutamate receptors in early developing binaural auditory neurons.The Journal of physiology · 2012Article
- Two GABAA responses with distinct kinetics in a sound localization circuit.The Journal of physiology · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Nucleus laminaris (NL) neurons encode interaural time difference (ITD), the cue used to localize low-frequency sounds. A physiologically based model of NL input suggests that ITD information is contained in narrow frequency bands around harmonics of the sound frequency. This suggested a theory, which predicts that, for each tone frequency, there is an optimal time course for synaptic inputs to NL that will elicit the largest modulation of NL firing rate as a function of ITD. The theory also suggested that neurons in different tonotopic regions of NL require specialized tuning to take advantage of the input gradient. Tonotopic tuning in NL was investigated in brain slices by separating the nucleus into three regions based on its anatomical tonotopic map. Patch-clamp recordings in each region were used to measure both the synaptic and the intrinsic electrical properties. The data revealed a tonotopic gradient of synaptic time course that closely matched the theoretical predictions. We also found postsynaptic band-pass filtering. Analysis of the combined synaptic and postsynaptic filters revealed a frequency-dependent gradient of gain for the transformation of tone amplitude to NL firing rate modulation. Models constructed from the experimental data for each tonotopic region demonstrate that the tonotopic tuning measured in NL can improve ITD encoding across sound frequencies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.