ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 106 citations in OpenAlex.
- Glutamate tone in preBötzinger complex rhythmogenesis: ambient extracellular glutamate as a candidate excitability bias.Pflugers Archiv : European journal of physiology · 2026Review
- Functional synaptic interactions and inhibitory circuitry of the pre-Bötzinger complex in the rhythmic slice.Journal of neurophysiology · 2026Article
- Brainstem Circuits for Rhythm Generation and Coordination of Orofacial Movements.Annual review of neuroscience · 2026Review
- Functional Synaptic Interactions and Inhibitory Circuitry of the PreBötzinger Complex in the Rhythmic Slice.bioRxiv : the preprint server for biology · 2026Article
- The sympathoregulatory region of the mouse rostral brainstem relies on both GABA and glycine to generate inhibitory currents.The Journal of physiology · 2026Article
- Inhibitory Subpopulations in preBötzinger Complex Play Distinct Roles in Modulating Inspiratory Rhythm and Pattern.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cell types and synchronous-activity patterns of inspiratory neurons in the preBötzinger complex of mouse medullary slices during early postnatal development.Scientific reports · 2023Article
- Breathing Rhythm and Pattern and Their Influence on Emotion.Annual review of neuroscience · 2022Review
- The role of glycinergic inhibition in respiratory pattern formation and cardio-respiratory coupling in rats.Current research in physiology · 2021Article
- PreBötzinger complex neurons drive respiratory modulation of blood pressure and heart rate.eLife · 2020Article
- Emergent Elements of Inspiratory Rhythmogenesis: Network Synchronization and Synchrony Propagation.Neuron · 2020Article
- Monosynaptic Projections to Excitatory and Inhibitory preBötzinger Complex Neurons.Frontiers in neuroanatomy · 2020Article
- Insights into the dynamic control of breathing revealed through cell-type-specific responses to substance P.eLife · 2019Article
- Muscarinic Modulation of Morphologically Identified Glycinergic Neurons in the Mouse PreBötzinger Complex.Frontiers in cellular neuroscience · 2019Article
- Advances in cellular and integrative control of oxygen homeostasis within the central nervous system.The Journal of physiology · 2018Review
- The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time.Annual review of neuroscience · 2018Review
- Breathing matters.Nature reviews. Neuroscience · 2018Review
- Organization of the core respiratory network: Insights from optogenetic and modeling studies.PLoS computational biology · 2018Article
- The interdependence of excitation and inhibition for the control of dynamic breathing rhythms.Nature communications · 2018Article
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3 authors at 2 institutions in 2 countries.
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Abstract
The preBötzinger complex (preBötC) is essential for normal respiratory rhythm generation in rodents, for which the underlying mechanisms remain unknown. Excitatory preBötC pacemaker neurons are proposed to be necessary for rhythm generation. Here we report the presence of a population of preBötC glycinergic pacemaker neurons. We used rhythmic in vitro transverse slice preparations from transgenic mice where neurons expressing the glycine transporter 2 (GlyT2) gene coexpress enhanced green fluorescent protein (EGFP). We combined epifluorescence and whole-cell patch-clamp recording to study preBötC EGFP-labeled, i.e., glycinergic, inspiratory-modulated neurons with pacemaker properties. We defined glycinergic pacemaker neurons as those preBötC EGFP neurons that exhibited the following: (1) ectopic bursting in rhythmic slices when depolarized during their normally silent period and (2) bursting when depolarized in nonrhythmic slices (following AMPA receptor blockade). Forty-two percent of EGFP-labeled neurons were inspiratory (n = 48 of 115), of which 23% (n = 11 of 48 inspiratory; 10% of the total recorded) were pacemakers. We conclude that there is a population of preBötC inspiratory-modulated glycinergic, presumably inhibitory, pacemaker neurons that constitute a substantial fraction of all preBötC pacemaker neurons. These findings challenge contemporary models for respiratory rhythmogenesis that assume the excitatory nature of preBötC pacemaker neurons. Testable and nontrivial predictions of the functional role of excitatory and inhibitory pacemaker neurons need to be proposed and the necessary experiments performed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.