ArticleJournal of virology2010
Comprehensive analysis of Rhesus lymphocryptovirus microRNA expression.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 44 citations in OpenAlex.
- Inhibition of type I interferon signaling is a conserved function of gamma-herpesvirus-encoded microRNAs.Journal of virology · 2026Article
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- The miRNA: a small but powerful RNA for COVID-19.Briefings in bioinformatics · 2021Review
- Crosstalk Between Mammalian Antiviral Pathways.Non-coding RNA · 2019Review
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- Integrated analysis of mRNA and viral miRNAs in the kidney of Carassius auratus gibelio response to cyprinid herpesvirus 2.Scientific reports · 2017Article
- Expression profile of Epstein-Barr virus and human adenovirus small RNAs in tonsillar B and T lymphocytes.PloS one · 2017Article
- Human Absorbable MicroRNA Prediction based on an Ensemble Manifold Ranking Model.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2015Article
- Viral noncoding RNAs: more surprises.Genes & development · 2015Review
- Computational Characterization of Exogenous MicroRNAs that Can Be Transferred into Human Circulation.PloS one · 2015Article
- EBV Noncoding RNAs.Current topics in microbiology and immunology · 2015Review
- Identification and Characterization of Cyprinid Herpesvirus-3 (CyHV-3) Encoded MicroRNAs.PloS one · 2015Article
- The porcine microRNA transcriptome response to transmissible gastroenteritis virus infection.PloS one · 2015Article
- Evolutionary conservation of primate lymphocryptovirus microRNA targets.Journal of virology · 2014Article
- RNA families in Epstein-Barr virus.RNA biology · 2014Review
- Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells.Cell host & microbe · 2013Article
- γ-Herpesvirus-encoded miRNAs and their roles in viral biology and pathogenesis.Current opinion in virology · 2013Review
- Association of Argonaute proteins and microRNAs can occur after cell lysis.RNA (New York, N.Y.) · 2012Article
- EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency.The EMBO journal · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Rhesus lymphocryptovirus (rLCV) and Epstein-Barr virus (EBV) are closely related gammaherpesviruses that infect and cause disease in rhesus monkeys and humans, respectively. Thus, rLCV is an important model system for EBV pathogenesis. Both rLCV and EBV express microRNAs (miRNAs), several conserved in sequence and genomic location. We have applied deep sequencing technology to obtain an inventory of rLCV miRNA expression in latently rLCV-infected monkey B cells. Our data confirm the presence of all previously identified mature rLCV miRNAs and have resulted in the discovery of 21 new mature miRNAs arising from previously identified precursor miRNAs (pre-miRNAs), as well as two novel pre-miRNAs (rL1-34 and rL1-35) that together generate four new mature miRNAs. Thus, the total number of rLCV-encoded pre-miRNAs is 35 and the total number of rLCV mature miRNAs is 68, the most of any virus examined. The exact 5' and 3' ends of all mature rLCV miRNAs were pinpointed, many showing marked sequence and length heterogeneity that could modulate function. We further demonstrate that rLCV mature miRNAs associate with Argonaute proteins in rLCV-infected B cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.