ArticleJournal of virology2010
The specificity of TRIM5 alpha-mediated restriction is influenced by its coiled-coil domain.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Characterization of Megabat-Favored, CA-Dependent Susceptibility to Retrovirus Infection.Journal of virology · 2023Article
- Updating on Roles of HIV Intrinsic Factors: A Review of Their Antiviral Mechanisms and Emerging Functions.Intervirology · 2022Review
- Characterization of the primate TRIM gene family reveals the recent evolution in primates.Molecular genetics and genomics : MGG · 2020Article
- Restriction of HIV-1 and other retroviruses by TRIM5.Nature reviews. Microbiology · 2019Review
- TRIM5 gene polymorphisms in HIV-1-infected patients and healthy controls from Northeastern Brazil.Immunologic research · 2016Article
- Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- CryoEM analysis of capsid assembly and structural changes upon interactions with a host restriction factor, TRIM5α.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Birth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- An evolutionary screen highlights canonical and noncanonical candidate antiviral genes within the primate TRIM gene family.Genome biology and evolution · 2013Article
- Identification of a genomic reservoir for new TRIM genes in primate genomes.PLoS genetics · 2011Article
- Modulation of TRIM5alpha activity in human cells by alternatively spliced TRIM5 isoforms.Journal of virology · 2011Article
- Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair.American journal of physiology. Cell physiology · 2011Article
- Unique spectrum of activity of prosimian TRIM5alpha against exogenous and endogenous retroviruses.Journal of virology · 2011Article
- Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction.The Journal of biological chemistry · 2011Article
- Novel escape mutants suggest an extensive TRIM5α binding site spanning the entire outer surface of the murine leukemia virus capsid protein.PLoS pathogens · 2011Article
- Rhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfaces.PLoS pathogens · 2011Article
- Recent insights into the mechanism and consequences of TRIM5α retroviral restriction.AIDS research and human retroviruses · 2011Review
- The antiviral spectra of TRIM5α orthologues and human TRIM family proteins against lentiviral production.PloS one · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retroviruses are both powerful evolutionary forces and dangerous threats to genome integrity. As such, they have imposed strong selective pressure on their hosts, notably triggering the emergence of restriction factors, such as TRIM5 alpha, that act as potent barriers to their cross-species transmission. TRIM5 alpha orthologues from different primates have distinct retroviral restriction patterns, largely dictated by the sequence of their C-terminal PRYSPRY domain, which binds the capsid protein of incoming virions. Here, by combining genetic and functional analyses of human and squirrel monkey TRIM5 alpha, we demonstrate that the coiled-coil domain of this protein, thus far essentially known for mediating oligomerization, also conditions the spectrum of antiretroviral activity. Furthermore, we identify three coiled-coil residues responsible for this effect, one of which has been under positive selection during primate evolution, notably in New World monkeys. These results indicate that the PRYSPRY and coiled-coil domains cooperate to determine the specificity of TRIM5 alpha-mediated capture of retroviral capsids, shedding new light on this complex event.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.