ArticleJournal of virology2010
Intrahost evolutionary dynamics of canine influenza virus in naive and partially immune dogs.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Impact of inactivated vaccine on transmission and evolution of H9N2 avian influenza virus in chickens.NPJ vaccines · 2025Article
- Experimental evidence of vaccine-driven evolution of respiratory syndrome virus type 2.Virus evolution · 2025Article
- Genetic drift and purifying selection shape within-host influenza A virus populations during natural swine infections.PLoS pathogens · 2024Article
- Genetic drift and purifying selection shape within-host influenza A virus populations during natural swine infections.bioRxiv : the preprint server for biology · 2023Article
- Vaccination decreases the risk of influenza A virus reassortment but not genetic variation in pigs.eLife · 2022Article
- Slowing Influenza Virus Evolution: A Role for Multiple Synergistic Antiviral Specificities in Vaccination Strategies.Viral immunology · 2020Article
- Local immune and microbiological responses to mucosal administration of a Liposome-TLR agonist immunotherapeutic in dogs.BMC veterinary research · 2019Article
- Diversity and distribution of type A influenza viruses: an updated panorama analysis based on protein sequences.Virology journal · 2019Article
- Nanopore sequencing for rapid diagnostics of salmonid RNA viruses.Scientific reports · 2018Article
- Mutation W222L at the Receptor Binding Site of Hemagglutinin Could Facilitate Viral Adaption from Equine Influenza A(H3N8) Virus to Dogs.Journal of virology · 2018Article
- Within-Host Evolution of Human Influenza Virus.Trends in microbiology · 2018Review
- Zoonotic Influenza and Human Health-Part 1: Virology and Epidemiology of Zoonotic Influenzas.Current infectious disease reports · 2018Review
- Is seasonal vaccination a contributing factor to the selection of influenza epidemic variants?Human vaccines & immunotherapeutics · 2018Article
- Population Diversity and Collective Interactions during Influenza Virus Infection.Journal of virology · 2017Review
- Multiple Genome Constellations of Similar and Distinct Influenza A Viruses Co-Circulate in Pigs During Epidemic Events.Scientific reports · 2017Article
- Complete Genome Sequencing of Influenza A Viruses within Swine Farrow-to-Wean Farms Reveals the Emergence, Persistence, and Subsidence of Diverse Viral Genotypes.Journal of virology · 2017Article
- Getting the flu: 5 key facts about influenza virus evolution.PLoS pathogens · 2017Review
- Transmission Bottleneck Size Estimation from Pathogen Deep-Sequencing Data, with an Application to Human Influenza A Virus.Journal of virology · 2017Article
- Article
- Multiple Sources of Genetic Diversity of Influenza A Viruses during the Hajj.Journal of virology · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The patterns and dynamics of evolution in acutely infecting viruses within individual hosts are largely unknown. To this end, we investigated the intrahost variation of canine influenza virus (CIV) during the course of experimental infections in naïve and partially immune dogs and in naturally infected dogs. Tracing sequence diversity in the gene encoding domain 1 of the hemagglutinin (HA1) protein over the time course of infection provided information on the patterns and processes of intrahost viral evolution and revealed some of the effects of partial host immunity. Viral populations sampled on any given day were generally characterized by mean pairwise genetic diversities between 0.1 and 0.2% and by mutational spectra that changed considerably on different days. Some observed mutations may have affected antigenicity or host range, including reversions of CIV host-associated mutations. Patterns of sequence diversity differed between naïve and vaccinated dogs, with some presumably antigenic mutations transiently reaching high frequency in the latter. CIV populations are therefore characterized by the rapid generation and clearance of genetic diversity. Potentially advantageous mutations arise readily during the course of single infections and may give rise to antigenic escape or host range variants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.