ArticleMolecular endocrinology (Baltimore, Md.)2010
Research resource: expression profiling reveals unexpected targets and functions of the human steroid receptor RNA activator (SRA) gene.
Article in Molecular endocrinology (Baltimore, Md.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
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- LncRNAs regulate ferroptosis to affect diabetes and its complications.Frontiers in physiology · 2022Review
- LncRNA SRA mediates cell migration, invasion, and progression of ovarian cancer via NOTCH signaling and epithelial-mesenchymal transition.Bioscience reports · 2021Article
- The long noncoding RNA HOTAIRM1 controlled by AML1 enhances glucocorticoid resistance by activating RHOA/ROCK1 pathway through suppressing ARHGAP18.Cell death & disease · 2021Article
- Sex Disparities in COVID-19 Severity and Outcome: Are Men Weaker or Women Stronger?Neuroendocrinology · 2021Review
- Long Non-coding RNAs Involved in Metabolic Alterations in Breast and Prostate Cancers.Frontiers in oncology · 2020Review
- Progress in understanding the relationship between long noncoding RNA and endometriosis.European journal of obstetrics & gynecology and reproductive biology: X · 2020Review
- The Signaling Pathways Project, an integrated 'omics knowledgebase for mammalian cellular signaling pathways.Scientific data · 2019Article
- AAV9-Molecular therapy. Methods & clinical development · 2019Article
- Tributyltin chloride (TBT) induces RXRA down-regulation and lipid accumulation in human liver cells.PloS one · 2019Article
- Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets.Oncogene · 2018Article
- New Insights Into the Long Non-coding RNA SRA: Physiological Functions and Mechanisms of Action.Frontiers in medicine · 2018Review
- Long non-coding RNAs as novel biomarkers for breast cancer invasion and metastasis.Oncology letters · 2017Article
- A mutation in the TMEM65 gene results in mitochondrial myopathy with severe neurological manifestations.European journal of human genetics : EJHG · 2017Article
- Insights from Global Analyses of Long Noncoding RNAs in Breast Cancer.Current pathobiology reports · 2017Article
- Decreased expression of LncRNA SRA1 in hepatocellular carcinoma and its clinical significance.Cancer biomarkers : section A of Disease markers · 2017Article
- Truncated SRA RNA derivatives inhibit estrogen receptor-α-mediated transcription.Molecular biology reports · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The human steroid receptor RNA activator (SRA) gene encodes both noncoding RNAs (ncRNAs) and protein-generating isoforms. In reporter assays, SRA ncRNA enhances nuclear receptor and myogenic differentiation 1 (MyoD)-mediated transcription but also participates in specific corepressor complexes, serving as a distinct scaffold. That SRA RNA levels might affect some biological functions, such as proliferation, apoptosis, steroidogenesis, and myogenesis, has been reported. However, the breadth of endogenous target genes that might be regulated by SRA RNAs remains largely unknown. To address this, we depleted SRA RNA in two human cancer cell lines with small interfering RNAs and then assayed for changes in gene expression by microarray analyses. The majority of significantly changed genes were reduced upon SRA knockdown, implicating SRA RNAs as endogenous coactivators. Unexpectedly, only a small subset of direct estrogen receptor-alpha target genes was affected in estradiol-treated MCF-7 cells. Eight bona fide SRA downstream target genes were identified (SLC2A3, SLC2A12, CCL20, TGFB2, DIO2, TMEM65, TBL1X, and TMPRSS2), representing entirely novel SRA targets, except for TMPRSS2. These data suggest unanticipated roles for SRA in glucose uptake, cellular signaling, T(3) hormone generation, and invasion/metastasis. SRA depletion in MDA-MB-231 cells reduced invasiveness and expression of some genes critical for this process. Consistent with the knockdown data, overexpressed SRA ncRNA coactivates certain target promoters and may enhance the activity of some coregulatory proteins. This study is a valuable resource because it represents the first genome-wide analysis of a mammalian RNA coregulator.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.