ArticleAmerican journal of physiology. Renal physiology2010
Heterogeneous stock rats: a new model to study the genetics of renal phenotypes.
Article in American journal of physiology. Renal physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 36 citations in OpenAlex.
- Point mutations and complex variants impact gene expression and addiction-related behaviors in Heterogeneous Stock rats.bioRxiv : the preprint server for biology · 2026Article
- Independent Heritability of Aversive Learning Influences on Cocaine-Seeking and Punishment Resistance in Rats.eNeuro · 2026Article
- Dissociation of intake and incentive sensitization during intermittent- and continuous-access heroin self-administration in rats.Psychopharmacology · 2025Article
- Modeling Brain Gene Expression in Alcohol Use Disorder with Genetic Animal Models.Current topics in behavioral neurosciences · 2025Review
- 2022 updates to the Rat Genome Database: a Findable, Accessible, Interoperable, and Reusable (FAIR) resource.Genetics · 2023Article
- A generic hidden Markov model for multiparent populations.G3 (Bethesda, Md.) · 2022Article
- Nephron-deficient HSRA rats exhibit renal injury with age but have limited renal damage from streptozotocin-induced hyperglycemia.American journal of physiology. Renal physiology · 2021Article
- Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model.Scientific reports · 2021Article
- High-fat diet negatively impacts both metabolic and behavioral health in outbred heterogeneous stock rats.Physiological genomics · 2020Article
- Using Genetic and Species Diversity to Tackle Kidney Disease.Trends in genetics : TIG · 2020Review
- Whole genome sequencing and novel candidate genes for CAKUT and altered nephrogenesis in the HSRA rat.Physiological genomics · 2020Article
- Extended regions of suspected mis-assembly in the rat reference genome.Scientific data · 2019Article
- Using Heterogeneous Stocks for Fine-Mapping Genetically Complex Traits.Methods in molecular biology (Clifton, N.J.) · 2019Review
- Automatic glomerular identification and quantification of histological phenotypes using image analysis and machine learning.American journal of physiology. Renal physiology · 2018Article
- Article
- Heterogeneous Stock Populations for Analysis of Complex Traits.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Premature responding is associated with approach to a food cue in male and female heterogeneous stock rats.Psychopharmacology · 2016Article
- Spontaneous one-kidney rats are more susceptible to develop hypertension by DOCA-NaCl and subsequent kidney injury compared with uninephrectomized rats.American journal of physiology. Renal physiology · 2016Article
- Nephron Deficiency and Predisposition to Renal Injury in a Novel One-Kidney Genetic Model.Journal of the American Society of Nephrology : JASN · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic kidney disease is a growing medical concern, with an estimated 25.6 million people in the United States exhibiting some degree of kidney injury and/or decline in kidney function. Animal models provide great insight into the study of the genetics of complex diseases. In particular, heterogeneous stock (HS) rats represent a unique genetic resource enabling rapid fine-mapping of complex traits. However, they have not been explored as a model to study renal phenotypes. To evaluate the usefulness of HS rats in the genetics of renal traits, a time course evaluation (weeks 8-40) was performed for several renal phenotypes. As expected, a large degree of variation was seen for most renal traits. By week 24, three (of 40) rats exhibited marked proteinuria that increased gradually until week 40 and ranged from 33.7 to 80.2 mg/24 h. Detailed histological analysis confirmed renal damage in these rats. In addition, several rats consistently exhibited significant hematuria (5/41). Interestingly, these rats were not the same rats that exhibited proteinuria, indicating that susceptibility to different types of kidney injury is likely segregating within the HS population. One HS rat exhibited unilateral renal agenesis (URA), which was accompanied by a significant degree of proteinuria and glomerular and tubulointerstitial injury. The parents of this HS rat were identified and bred further. Additional offspring of this pair were observed to exhibit URA at frequency between 40% and 60%. In summary, these novel data demonstrate that HS rats exhibit variation in proteinuria and other kidney-related traits, confirming that the model harbors susceptibility alleles for kidney injury and providing the basis for further genetic studies.
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