ArticleJournal of proteomics2010
Characterization of potential allergens in fenugreek (Trigonella foenum-graecum) using patient sera and MS-based proteomic analysis.
Article in Journal of proteomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 46 citations in OpenAlex.
- The ALLPreT panel of legume allergen preparations: characterization of optimized protein extracts for allergen composition, IgE-binding and IgE-crosslinking properties.Frontiers in allergy · 2026Article
- Spices, herbs and allergic reactions in children: myth or reality - a narrative review with scoping elements.Frontiers in allergy · 2025Review
- Legume Allergens Pea, Chickpea, Lentil, Lupine and Beyond.Current allergy and asthma reports · 2024Review
- IgE-Mediated Legume Allergy: A Pediatric Perspective.Journal of personalized medicine · 2024Review
- Fenugreek allergy caused by cross-reactivity with peanut: AnThe journal of allergy and clinical immunology. Global · 2024Article
- Rare causes of pediatric anaphylaxis due to obscure allergens.Frontiers in allergy · 2024Review
- Hidden and Rare Food Allergens in Pediatric Age.Nutrients · 2023Review
- Vegan diets from an allergy point of view - Position paper of the DGAKI working group on food allergy.Allergologie select · 2023Article
- Food-Induced Anaphylaxis: Role of Hidden Allergens and Cofactors.Frontiers in immunology · 2019Review
- Characterisation of potential novel allergens in the fish parasiteEuPA open proteomics · 2014Article
- Complementary, holistic, and integrative medicine: advice for clinicians on herbs and breastfeeding.Pediatrics in review · 2013Review
- Fenugreek Anaphylaxis in a Pediatric Patient.Allergy & rhinology (Providence, R.I.)Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundFenugreek is a legume plant used as an ingredient of curry spice. Incidents of IgE-mediated food allergy to fenugreek have been reported. Coincidence with allergy to peanut, a major food allergen, seems to be common suggesting a rather high rate of cross-reactivity.
objectiveCharacterization of fenugreek allergens using patient sera and mass spectrometry-based proteomic analysis.
methodsAllergenic fenugreek proteins were detected by immunoblotting, using sera from 13 patients with specific IgE to peanut and fenugreek. IgE-binding proteins were analyzed by peptide mass fingerprinting and peptide sequencing.
resultsA fenugreek protein quintet in the range from 50 kDa to 66 kDa showed high IgE-affinity, the protein at 50 kDa reaching the strongest signals in all patients. Proteomic analyses allowed the classification of several fenugreek proteins to a number of allergen families. Fenugreek 7S-vicilin and 11S-legumin were partly sequenced and revealed considerable homologies to peanut Ara h 1 and Ara h 3, respectively. The presence of a fenugreek 2S albumin and pathogenesis-related (PR-10) plant pollen protein was assumed by database searching results.
conclusionIn this study, individual fenugreek proteins were characterised for the first time. Observed homologies to major peanut allergens provide a molecular explanation for clinical cross-reactivity.
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