ArticleMechanisms of ageing and development2010
Protein phosphatase 2A (PP2A) is increased in old murine B cells and mediates p38 MAPK/tristetraprolin dephosphorylation and E47 mRNA instability.
Article in Mechanisms of ageing and development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review).Molecular medicine reports · 2026Review
- Counteracting Immunosenescence-Which Therapeutic Strategies Are Promising?Biomolecules · 2023Review
- Article
- Myc-Interacting Zinc Finger Protein 1 (Miz-1) Is Essential to Maintain Homeostasis and Immunocompetence of the B Cell Lineage.Biology · 2022Article
- Leptin induces immunosenescence in human B cells.Cellular immunology · 2020Article
- Obesity Accelerates Age Defects in Mouse and Human B Cells.Frontiers in immunology · 2020Review
- Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration.Pharmacology & therapeutics · 2019Review
- MAPK p38 regulates inflammatory gene expression via tristetraprolin: Doing good by stealth.The international journal of biochemistry & cell biology · 2018Review
- Obesity induces pro-inflammatory B cells and impairs B cell function in old mice.Mechanisms of ageing and development · 2017Article
- The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases.Biochemical Society transactions · 2016Review
- Metallothionein regulates intracellular zinc signaling during CD4(+) T cell activation.BMC immunology · 2016Article
- Obesity decreases B cell responses in young and elderly individuals.Obesity (Silver Spring, Md.) · 2016Article
- Review
- Tristetraprolin Recruits Eukaryotic Initiation Factor 4E2 To Repress Translation of AU-Rich Element-Containing mRNAs.Molecular and cellular biology · 2015Article
- MicroRNAs miR-155 and miR-16 Decrease AID and E47 in B Cells from Elderly Individuals.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Protein phosphatase 2A is involved in the tyrosine hydroxylase phosphorylation regulated by α-synuclein.Neurochemical research · 2015Article
- Post-transcriptional regulation of cytokine signaling by AU-rich and GU-rich elements.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2014Review
- Age effects on mouse and human B cells.Immunologic research · 2013Review
- Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues.Aging and disease · 2011Article
- E47 retroviral rescue of intrinsic B-cell defects in senescent mice.Aging cell · 2011Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
The transcription factor E47, which regulates immunoglobulin class switch in murine splenic B cells, is down-regulated in aged B cells due to reduced mRNA stability. Part of the decreased stability of E47 mRNA is mediated by tristetraprolin (TTP), a physiological regulator of mRNA stability. We have previously shown that TTP mRNA and protein expression are higher in old B cells, and the protein is less phosphorylated in old B cells, both of which lead to more binding of TTP to the 3'-UTR of E47 mRNA, thereby decreasing its stability. PP2A is a protein phosphatase that plays an important role in the regulation of a number of major signaling pathways. Herein we show that not only the amount but also the activity of PP2A is increased in old B cells. As a consequence of this higher phosphatase activity in old B cells, p38 MAPK and TTP (either directly or indirectly by PP2A) are less phosphorylated as compared with young B cells. PP2A dephosphorylation of p38 MAPK and/or TTP likely generates more binding of the hypophosphorylated TTP to the E47 mRNA, inducing its degradation. This mechanism may be at least in part responsible for the age-related decrease in class switch.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.