ArticleJournal of the American Society for Mass Spectrometry2010
Influence of amino acid side chains on apparent selective opening of cyclic b5 ions.
Article in Journal of the American Society for Mass Spectrometry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Exploitation of the Ornithine Effect Enhances Characterization of Stapled and Cyclic Peptides.Journal of the American Society for Mass Spectrometry · 2016Article
- Peptide scrambling during collision-induced dissociation is influenced by N-terminal residue basicity.Journal of the American Society for Mass Spectrometry · 2014Article
- Gas-phase ion isomer analysis reveals the mechanism of peptide sequence scrambling.Analytical chemistry · 2014Article
- Evidence for sequence scrambling and divergent H/D exchange reactions of doubly-charged isobaric b-type fragment ions.Journal of the American Society for Mass Spectrometry · 2014Article
- Non-direct sequence ions in the tandem mass spectrometry of protonated peptide amides--an energy-resolved study.Journal of the American Society for Mass Spectrometry · 2013Article
- Fragmentation reactions of methionine-containing protonated octapeptides and fragment ions therefrom: an energy-resolved study.Journal of the American Society for Mass Spectrometry · 2013Article
- Spectroscopic identification of cyclic imide b2-ions from peptides containing Gln and Asn residues.Journal of the American Society for Mass Spectrometry · 2013Article
- Selective deletion of the internal lysine residue from the peptide sequence by collisional activation.Journal of the American Society for Mass Spectrometry · 2012Article
- Investigation of scrambled ions in tandem mass spectra. Part 1. Statistical characterization.Journal of the American Society for Mass Spectrometry · 2012Article
- The influence glutamic acid in protonated bInternational journal of mass spectrometry · 2012Article
- Conformation-specific spectroscopy of peptide fragment ions in a low-temperature ion trap.Journal of the American Society for Mass Spectrometry · 2012Article
- Fragmentation reactions of b(5) and a (5) ions containing proline--the structures of a(5) ions.Journal of the American Society for Mass Spectrometry · 2012Article
- Spectroscopic evidence for an oxazolone structure in anionic b-type peptide fragments.Journal of the American Society for Mass Spectrometry · 2012Article
- Occurrence of C-terminal residue exclusion in peptide fragmentation by ESI and MALDI tandem mass spectrometry.Journal of the American Society for Mass Spectrometry · 2012Article
- Electrospray ionization mass spectrometry: a technique to access the information beyond the molecular weight of the analyte.International journal of analytical chemistry · 2012Article
- Mass spectrometry analysis of 2-nitrophenylhydrazine carboxy derivatized peptides.Journal of the American Society for Mass Spectrometry · 2011Article
- Sequence elucidation of an unknown cyclic peptide of high doping potential by ETD and CID tandem mass spectrometry.Journal of the American Society for Mass Spectrometry · 2011Article
- Structural heterogeneity of doubly-charged peptide b-ions.Journal of the American Society for Mass Spectrometry · 2011Article
- Sequencing Lys-N proteolytic peptides by ESI and MALDI tandem mass spectrometry.Journal of the American Society for Mass Spectrometry · 2011Article
- A systematic study of acidic peptides for b-type sequence scrambling.Journal of the American Society for Mass Spectrometry · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, the possible influence of acidic, basic, and amide side chains on the opening of a putative macrocyclic b ion (b(5)(+)) intermediate was investigated. Collision induced dissociation (CID) of b(5) ions was studied using a group of hexapeptides in which amino acids with the side chains of interest occupied internal sequence positions. Further experiments were performed with permuted isomers of glutamine (Q) containing peptides to probe for sequence scrambling and whether the specific sequence site of the residues influences opening of the macrocycle. Overall, the trend for (apparent) preferential/selective opening of the cyclic b(5)(+), presumably due to the side chain, followed by the loss of the amino acid with active side group is: Q > K > D > N approximately E.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.