Evidence map›Paper›PMID 20219237›Full record

ArticleThe Science of the total environment2010

Exposure to polycyclic aromatic hydrocarbons and missed abortion in early pregnancy in a Chinese population.

Jun Wu, Haiyan Hou, Beate Ritz, Yaqiong Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Science of the total environment, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
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  14. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2021
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  17. Toxicological Effects of BPDE on Dysfunctions of Female Trophoblast Cells.Advances in experimental medicine and biology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jun WuProgram in Public Health and Department of Epidemiology, College of Health Sciences, University of California, Irvine, California, USA.
Haiyan Hou
Beate Ritz
Yaqiong Chen
Chinese People's Armed Police ForceUniversity of California, Irvine · USUniversity of California, Los Angeles · US

Funding

Exposure to mobile source air pollution and adverse birth outcomes in the Los AngR21ES016379 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI WU, JUN · 2008 to 2009
$552k
NIEHS NIH HHS 1R21ES016379-01A1NIEHS NIH HHS R21 ES016379
6 · The paper itself

Abstract

backgroundPolycyclic aromatic hydrocarbons (PAHs) are formed during incomplete burning of fossil fuels, wood, and tobacco products. High PAH exposure has been associated with low birth weight, intrauterine growth restriction, and preterm birth, but little is known about its impact on adverse outcomes in early pregnancy such as in-utero fetal death.

objectivesTo examine associations between exposure to PAHs and missed abortion in which the embryo has died but a miscarriage has not yet occurred during early pregnancy in a Chinese population in Tianjin.

methodsA case-control study was conducted from April to November, 2007 in Tianjin, China. Cases experienced a missed abortion while controls underwent elective abortions before 14weeks of pregnancy. Eighty-one cases were recruited from four hospitals, with the same number of controls matched on hospital, maternal age (+/-8years), gravidity (1 or >1), and gestational age (+/-30days). Two maternal measures of PAH exposures were obtained based on benzo[a]pyrene (BaP) DNA adducts in 1) aborted tissues and 2) maternal blood (for a subset of subjects). In addition, proxy measures for PAH exposures from different sources were derived from maternal interviews.

resultsIn conditional logistic regression analyses, we estimated more than 4-fold increase in risk of having experienced a missed abortion in women with above the median levels of blood BaP-DNA adducts (adjusted OR=4.27; 95% CI, 1.41-12.99); but no increase with adduct levels in aborted tissues (adjusted OR=0.76; 95% CI, 0.37-1.54). BaP-DNA adduct levels in maternal blood and aborted tissues were poorly correlated (r=-0.12; n=102). Missed abortion risk also was higher among women reporting traffic congestion near the residence, commuting by walking, and performing regular cooking activities during pregnancy.

conclusionHigh levels of maternal PAH exposures may contribute to an increased risk of experiencing a missed abortion during early pregnancy.

Indexed as

Abortion, MissedAdultAir PollutantsCase-Control StudiesChinaEnvironmental ExposureEnvironmental MonitoringEpidemiological MonitoringFemaleGestational AgeHumansMaternal ExposurePolycyclic Aromatic HydrocarbonsPregnancyYoung AdultAir PollutantsPolycyclic Aromatic Hydrocarbons

Identifiers

PMID20219237
PMCPMC10916680
OpenAlexW2013805081

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.