ArticleVirology2010
Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanger expression.
Article in Virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Prospects for the use of viral proteins for the construction of chimeric toxins.Archives of virology · 2024Review
- An Insight into the Molecular Characteristics and Associated Pathology of Chicken Astroviruses.Viruses · 2022Review
- Pathogenesis of Chicken Astrovirus Related Illnesses.Frontiers in veterinary science · 2022Review
- Matrix Metalloproteinase MMP-12 Promotes Macrophage Transmigration Across Intestinal Epithelial Tight Junctions and Increases Severity of Experimental Colitis.Journal of Crohn's & colitis · 2021Article
- Pathogenesis of murine astrovirus in experimentally infected mice.Experimental animals · 2021Article
- Visualization of intestinal infections with astro- and sapovirus in mink (FEMS microbes · 2021Article
- Molecular Characterization and Determination of Relative Cytokine Expression in Naturally Infected Day-Old Chicks with Chicken Astrovirus Associated to White Chick Syndrome.Animals : an open access journal from MDPI · 2020Article
- Decreased NHE3 activity and trafficking in TGEV-infected IPEC-J2 cells via the SGLT1-mediated P38 MAPK/AKt2 pathway.Virus research · 2020Article
- Astrovirus and the microbiome.Current opinion in virology · 2019Review
- Characterizing a Murine Model for Astrovirus Using Viral Isolates from Persistently Infected Immunocompromised Mice.Journal of virology · 2019Article
- Pathophysiology of avian intestinal ion transport.World's poultry science journal · 2018Article
- Human rotavirus strain Wa downregulates NHE1 and NHE6 expressions in rotavirus-infected Caco-2 cells.Virus genes · 2017Article
- Astrovirus Pathogenesis.Viruses · 2017Review
- Pathophysiology of Intestinal NaCellular and molecular gastroenterology and hepatology · 2017Article
- The Immune Response to Astrovirus Infection.Viruses · 2016Review
- Oral Administration of Astrovirus Capsid Protein Is Sufficient To Induce Acute Diarrhea In Vivo.mBio · 2016Article
- Infectious causes of necrotizing enterocolitis.Clinics in perinatology · 2015Review
- Article
- Surveillance of Human Astrovirus Infection in Brazil: The First Report of MLB1 Astrovirus.PloS one · 2015Article
- Human astroviruses.Clinical microbiology reviews · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Astroviruses are known to be a leading cause of diarrhea in infants and the immunocompromised; however, our understanding of this endemic pathogen is limited. Histological analyses of astrovirus pathogenesis demonstrate clinical disease is not associated with changes to intestinal architecture, inflammation, or cell death. Recent studies in vitro have suggested that astroviruses induce actin rearrangement leading to loss of barrier function. The current study used the type-2 turkey astrovirus (TAstV-2) and turkey poult model of astrovirus disease to examine how astrovirus infection affects the ultrastructure and electrophysiology of the intestinal epithelium. These data demonstrate that infection results in changes to the epithelial ultrastructure, rearrangement of F-actin, decreased absorption of sodium, as well as redistribution of the sodium/hydrogen exchanger 3 (NHE3) from the membrane to the cytoplasm. Collectively, these data suggest astrovirus infection induces sodium malabsorption, possibly through redistribution of specific sodium transporters, which results in the development of an osmotic diarrhea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.