ArticleJournal of neuro-oncology2010
CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples.
Article in Journal of neuro-oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma.HemaSphere · 2024Article
- Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A.Molecular medicine reports · 2020Article
- Bioinformatics Analysis Reveals Biomarkers With Cancer Stem Cell Characteristics in Lung Squamous Cell Carcinoma.Frontiers in genetics · 2020Article
- Circular RNA circ_0007142 Facilitates Colorectal Cancer Progression by Modulating CDC25A Expression via miR-122-5p.OncoTargets and therapy · 2020Article
- Review
- Integrated analysis of competing endogenous RNA network revealing potential prognostic biomarkers of hepatocellular carcinoma.Journal of Cancer · 2019Article
- ATM in breast and brain tumors: a comprehensive review.Cancer biology & medicine · 2018Article
- The E3 ubiquitin ligase APC/CThe EMBO journal · 2017Article
- Knockdown of DIXDC1 Inhibits the Proliferation and Migration of Human Glioma Cells.Cellular and molecular neurobiology · 2017Article
- Linc00152 promotes malignant progression of glioma stem cells by regulating miR-103a-3p/FEZF1/CDC25A pathway.Molecular cancer · 2017Article
- Expression of estrogen and progesterone receptors in astrocytomas: a literature review.Clinics (Sao Paulo, Brazil) · 2016Review
- CHD1L Regulates Cell Cycle, Apoptosis, and Migration in Glioma.Cellular and molecular neurobiology · 2016Article
- MicroRNA miR-21 attenuates human cytomegalovirus replication in neural cells by targeting Cdc25a.Journal of virology · 2015Article
- Nuclear phosphorylated Y142 β-catenin accumulates in astrocytomas and glioblastomas and regulates cell invasion.Cell cycle (Georgetown, Tex.) · 2015Article
- Expression of NF45 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Expression of SPRR3 is associated with tumor cell proliferation and invasion in glioblastoma multiforme.Oncology letters · 2014Article
- Knockdown of LGR5 suppresses the proliferation of glioma cells in vitro and in vivo.Oncology reports · 2014Article
- Important miRs of pathways in different tumor types.PLoS computational biology · 2013Article
- Molecular network profiling of U373MG human glioblastoma cells following induction of apoptosis by novel marine-derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids.Cancer cell international · 2012Article
- Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma.Molecular oncology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell division cycle 25 (CDC25) phosphatases are cell-cycle regulatory proteins which are overexpressed in a significant number of human cancers. This study evaluated the role of CDC25 phosphatases in human glioma proliferation. Upregulation of CDC25A was observed in human glioma specimens and human glioma cell lines. Comparison of expression levels of CDC25A and CDC25B messenger ribonucleic acid (RNA) to Ki-67 labeling index in glioma tissues found that Ki-67 labeling index was significantly correlated with the expression of CDC25A, but not with that of CDC25B. Depletion of CDC25A by small interfering RNA and inhibition of CDC25 suppressed cell proliferation and induced apoptosis in glioma cell lines, indicating that CDC25A is a potential target for the development of new therapy for glioma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.