ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2010
Population-based resequencing analysis of improved wheat germplasm at wheat leaf rust resistance locus Lr21.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Advances in the Mining of Disease Resistance Genes fromPlants (Basel, Switzerland) · 2023Review
- Identification of induced mutations in hexaploid wheat genome using exome capture assay.PloS one · 2018Article
- Identification of a robust molecular marker for the detection of the stem rust resistance gene Sr45 in common wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2014Article
- Identification of candidate genes in rice for resistance to sheath blight disease by whole genome sequencing.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about the genetic impacts of modern plant breeding on specific breeding target loci. Resequencing cloned genes can identify all mutations in single genes for population-based analyses of genetic changes in improved gene pools. Ninety-five wheat cultivars released in Canada from 1845 to 2004 were sequenced at the wheat leaf rust resistance locus Lr21. Characterization of the DNA fragment of length 4,071 bp, covering the Lr21 gene from -92 to +4,261, revealed 13 SNPs, four indels, 10 haplotypes, and 4 major haplotype groups. A new SCAR marker was developed to identify the resistant haplotype and haplotype groups. Non-synonymous polymorphic sites and haplotype numbers were increased over the 100 years of wheat breeding. Nucleotide diversity of the wheat cultivars was gradually reduced from 1845 to 1993 and increased after the release of the first Lr21 wheat cultivar AC Cora in 1994. Positive selection measured with Tajima's D was observed in the cultivars released before 1935. At least two recombination events were inferred in those cultivars released before 1993. Linkage disequilibrium at the locus was decreased over time. These findings demonstrate not only the effectiveness of the wheat breeding in the improvement of leaf rust resistance, but also are useful to understand the genetic influences of a long-term artificial selection on individual loci.
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