ArticleMolecular biology reports2010
Oxidative stress induced by high-glucose diet in liver of C57BL/6J mice and its underlying mechanism.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 32 citations in OpenAlex.
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- Ameliorated effects of a lipopeptide surfactin on insulin resistance in vitro and in vivo.Food science & nutrition · 2022Article
- The glucotoxicity protecting effect of honokiol in human hepatocytesFrontiers in nutrition · 2022Article
- Hepatoprotective effect of silymarin on fructose induced nonalcoholic fatty liver disease in male albino wistar rats.BMC complementary medicine and therapies · 2021Article
- S-Nitrosoglutathione Reverts Dietary Sucrose-Induced Insulin Resistance.Antioxidants (Basel, Switzerland) · 2020Article
- High Glucose Induces Lipid Accumulation via 25-Hydroxycholesterol DNA-CpG Methylation.iScience · 2020Article
- Review
- Effect of liver fatty acid binding protein (L-FABP) gene ablation on lipid metabolism in high glucose diet (HGD) pair-fed mice.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Article
- Effect of High-Carbohydrate Diet on Plasma Metabolome in Mice with Mitochondrial Respiratory Chain Complex III Deficiency.International journal of molecular sciences · 2016Article
- Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease.Metabolism: clinical and experimental · 2016Review
- Quercetin Isolated fromJournal of diabetes research · 2016Article
- The use of transcriptomics to unveil the role of nutrients in Mammalian liver.ISRN nutrition · 2013Review
- Antioxidant N-acetylcysteine attenuates the reduction of Brg1 protein expression in the myocardium of type 1 diabetic rats.Journal of diabetes research · 2013Article
- Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver.Free radical biology & medicine · 2012Article
- Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats.Yonsei medical journal · 2012Article
- Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk.Molecular biology reports · 2012Article
- A novel 3D liver organoid system for elucidation of hepatic glucose metabolism.Biotechnology and bioengineering · 2012Article
- Hepatic mitochondrial alterations and increased oxidative stress in nutritional diabetes-prone Psammomys obesus model.Experimental diabetes research · 2012Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High glycemic index diet can induce multiple diseases. Many research indicated that oxidative stress played important role in many pathological conditions. However, the impact of gene expression and dietary habit on oxidation process are still less clear. We used high-glucose diet to feed C57BL/6J mice for 4 weeks, measured the redox status, physiological and biochemical changes related to diabetes and consequence of metabolic syndrome (nonalcoholic fatty liver, cardiovascular disease), and detected the expressions of 14,446 genes in liver of C57BL/6J mice with DNA microarray. The results showed high-glucose diet induced elevated fatty acid accumulation in liver, insulin resistance index and higher weight in C57BL/6J mice, which indicated high-glucose diet caused to the initiation and development of diabetes and consequence of metabolic syndrome. The results also showed high-glucose diet induced oxidative stress in liver of C57BL/6J mice, which might the cause of initiation and development of diabetes and consequence of metabolic syndrome. Microarray analysis found expressions of genes related to thiol redox, fatty acid oxidation in peroxisome and cytochrome P450 were significantly changed, indicating system in which non-enzyme antioxidant capacity was impaired and sources from which reactive oxygen species (ROS) generated, which revealed the molecular mechanism of oxidative stress induced by high-glucose diet. We validated our microarray findings by conducting real-time RT-PCR assays on selected genes.
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