ArticleJournal of clinical immunology2010
The nine-repeat DC-SIGNR isoform is associated with increased HIV-RNA loads and HIV sexual transmission.
Article in Journal of clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- The VNTR polymorphism of the DC-SIGNR gene and susceptibility to HIV-1 infection: a meta-analysis.PloS one · 2012Pooled it
- Immunopathogenesis of Different Emerging Viral Infections: Evasion, Fatal Mechanism, and Prevention.Frontiers in immunology · 2021Review
- Correlation of variable repeat number in the neck regions of DC-SIGN and DC-SIGNR with susceptibility to nasopharyngeal carcinoma in a Chinese population.Cancer management and research · 2018Article
- Association of CD209 and CD209L polymorphisms with tuberculosis infection in a Northeastern Brazilian population.Molecular biology reports · 2014Article
- The allele 4 of neck region liver-lymph node-specific ICAM-3-grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2014Article
- HIV-1 dynamics: a reappraisal of host and viral factors, as well as methodological issues.Viruses · 2012Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDetermine if different DC-SIGNR genotypes/alleles correlated with HIV susceptibility in the context of the HIV mode of infection, CD4+ T cell counts and blood HIV RNA loads.
methodsOne hundred forty-five HIV infected individuals and 187 uninfected healthy controls were recruited to observe whether DC-SIGNR genotypes/alleles were correlated with HIV susceptibility, CD4+ T cell numbers and HIV-RNA levels.
resultsThe frequencies of DC-SIGNR genotypes/alleles in HIV-infected patients were similar to those seen in the uninfected population. However, the 9-repeat DCSIGNR allele was more frequently found in patients infected via sexual transmission compared to patients infected via blood transmission/intravenous drug use (p = 0.005). HIV RNA levels in patients with the 9- or 7-repeat DC SIGNR allele were significantly higher than the levels observed in patients with the 5-repeat DC SIGNR allele (p = 0.004, p = 0.004, respectively) and the HIV RNA levels in patients with the 9/7 genotype or with the 7/7 genotype were significantly higher than patients with the 7/5 genotype (p = 0.003, p = 0.029, respectively). There were no significant differences between CD4+ T cells in patients with different DC-SIGNR genotypes/alleles.
conclusionsNo DC-SIGNR genotypes/alleles were associated with reduced HIV susceptibility, however, DC-SIGNR genotypes/alleles with higher repeat numbers were associated with higher HIV-RNA blood levels, that is, the 9-repeat DC-SIGNR allele was significantly associated with increased HIV-RNA levels and HIV sexual transmission.
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