ArticleImmunogenetics2010
SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine.
Article in Immunogenetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination.Human genetics · 2014Pooled it
- Human genetics of responses to vaccines.Clinical and experimental immunology · 2025Review
- Vaccinomics: Paving the Way for Personalized Immunization.Current pharmaceutical design · 2024Review
- Vaccinomics: A scoping review.Vaccine · 2023Article
- Mumps virus-specific immune response outcomes and sex-based differences in a cohort of healthy adolescents.Clinical immunology (Orlando, Fla.) · 2022Article
- Association of TNFRSF1A and IFNLR1 Gene Polymorphisms with the Risk of Developing Breast Cancer and Clinical Pathologic Features.Biochemical genetics · 2021Article
- Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor.Nature biomedical engineering · 2021Article
- Article
- Current Challenges in Vaccinology.Frontiers in immunology · 2020Review
- Polymorphisms in the Wilms Tumor Gene Are Associated With Interindividual Variations in Rubella Virus-Specific Cellular Immunity After Measles-Mumps-Rubella II Vaccination.The Journal of infectious diseases · 2018Article
- Recent Advances in Application of Pharmacogenomics for Biotherapeutics.The AAPS journal · 2016Review
- Rubella.Lancet (London, England) · 2015Review
- Polymorphisms in HLA-DPB1 are associated with differences in rubella virus-specific humoral immunity after vaccination.The Journal of infectious diseases · 2015Article
- Genetics and vaccines in the era of personalized medicine.Current genomics · 2015Article
- Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.Immunogenetics · 2014Article
- Associations between race, sex and immune response variations to rubella vaccination in two independent cohorts.Vaccine · 2014Article
- High-throughput assay optimization and statistical interpolation of rubella-specific neutralizing antibody titers.Clinical and vaccine immunology : CVI · 2014Article
- Article
- Characterization of humoral and cellular immunity to rubella vaccine in four distinct cohorts.Immunologic research · 2014Article
- Vaccines, reverse vaccinology, and bacterial pathogenesis.Cold Spring Harbor perspectives in medicine · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
An effective immune response to vaccination is, in part, a complex interaction of alleles of multiple genes regulating cytokine networks. We conducted a genotyping study of Th1/Th2/inflammatory cytokines/cytokine receptors in healthy children (n = 738, 11-19 years) to determine associations between individual single-nucleotide polymorphisms (SNPs)/haplotypes and immune outcomes after two doses of rubella vaccine. SNPs (n = 501) were selected using the ldSelect-approach and genotyped using Illumina GoldenGate and TaqMan assays. Rubella-IgG levels were measured by immunoassay and secreted cytokines by ELISA. Linear regression and post hoc haplotype analyses were used to determine associations between single SNPs/haplotypes and immune outcomes. Increased carriage of minor alleles for the promoter SNPs (rs2844482 and rs2857708) of the TNFA gene were associated with dose-related increases in rubella antibodies. IL-6 secretion was co-directionally associated (p < or = 0.01) with five intronic SNPs in the TNFRSF1B gene in an allele dose-related manner, while five promoter/intronic SNPs in the IL12B gene were associated with variations in IL-6 secretion. TNFA haplotype AAACGGGGC (t-statistic = 3.32) and IL12B promoter haplotype TAG (t-statistic = 2.66) were associated with higher levels of (p < or = 0.01) rubella-IgG and IL-6 secretion, respectively. We identified individual SNPs/haplotypes in TNFA/TNFRSF1B and IL12B genes that appear to modulate immunity to rubella vaccination. Identification of such "genetic fingerprints" may predict the outcome of vaccine response and inform new vaccine strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.