Evidence map›Paper›PMID 20217051›Full record

Trial reportPsychopharmacology2010

Differences in negative mood-induced smoking reinforcement due to distress tolerance, anxiety sensitivity, and depression history.

Kenneth A Perkins, Joshua L Karelitz, Grace E Giedgowd, Cynthia A Conklin, Michael A Sayette

Abstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

  1. Trial
  2. Anxiety Sensitivity and Distress Tolerance in Smokers: Relations With Tobacco Dependence, Withdrawal, and Quitting Success†.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
    Trial
  3. Trial
  4. Effects of 6-Week Use of Reduced-Nicotine Content Cigarettes in Smokers With and Without Elevated Depressive Symptoms.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017
    Trial
  5. Distress intolerance during smoking cessation treatment.Behaviour research and therapy · 2016
    Trial
  6. Trial
  7. Trial
  8. Financial Stress and Tobacco Expenditure in Australian Households: A Cross-Sectional Analysis of Prevalence and Association Across Wealth and Income Levels.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Potential Moderating Effects of Psychiatric Diagnosis and Symptom Severity on Subjective and Behavioral Responses to Reduced Nicotine Content Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Article
  18. Affective vulnerability in substance use disorders.Current opinion in psychology · 2019
    Review
  19. Article
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kenneth A PerkinsWestern Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. perkinska@upmc.edu
Joshua L Karelitz
Grace E Giedgowd
Cynthia A Conklin
Michael A Sayette

Funding

Tobacco Smoking, Nicotine and Negative Affect ReliefR01DA019478 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PERKINS, KENNETH ALAN · 2006 to 2009
$863k
Behavioral Genetics of Mood-Induced SmokingR03DA027449 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PERKINS, KENNETH ALAN · 2009 to 2010
$469k
NIDA NIH HHS DA027449NIDA NIH HHS DA19478NIDA NIH HHS R01 DA019478NIDA NIH HHS R03 DA027449
6 · The paper itself

Abstract

rationaleNegative mood increases smoking reinforcement and may do so to a greater degree in smokers vulnerable to negative mood dysregulation.

methodsAdult smokers (N = 71) without current depression were randomly assigned to one of two smoking conditions (nicotine or denic cigarettes, presented blind) maintained across all sessions. Subjects completed one neutral mood session and four negative mood induction sessions. Negative mood inductions included one each of the following: 1) overnight smoking abstinence, 2) challenging computer task, 3) public speech preparation, 4) watching negative mood slides. In each session, subjects took 4 puffs on their assigned cigarette, rated it for "liking" (reward), and then smoked those cigarettes ad libitum (reinforcement) during continued mood induction. Affect was assessed intermittently before and after smoking. Differences in responses were examined as functions of self-reported history of major depression and levels of distress tolerance and anxiety sensitivity.

resultsSmoking reinforcement, but not reward or negative affect relief, was greater in all sessions in those with a history of depression and greater after overnight abstinence in those with lower distress tolerance. Reward and affect relief, but not reinforcement, were greater during speech preparation among those high in anxiety sensitivity.

conclusionsLow distress tolerance may enhance acute smoking reinforcement due to abstinence, while depression history may broadly increase acute smoking reinforcement regardless of mood. Neither smoking reward nor affect help explain these individual differences in smoking reinforcement.

Indexed as

AffectReinforcement, PsychologyAdultAnxietyDepressionFemaleHumansMaleSmokingStress, Psychological

Identifiers

PMID20217051
PMCPMC2882096

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.