ArticleIntensive care medicine2010
Clinical relevance of 13 cytokine gene polymorphisms in Chinese major trauma patients.
Article in Intensive care medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 7 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 7 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Association Between IL10 Polymorphisms and the Susceptibility to Sepsis: A Meta-Analysis.Biochemical genetics · 2023Pooled it
- Immune capacity determines outcome following surgery or trauma: a systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Pooled it
- Association between the Lymphotoxin-BioMed research international · 2020Pooled it
- Genetic dissection of host immune response in pneumonia development and progression.Scientific reports · 2016Pooled it
- Association between interleukin-10 polymorphisms and sepsis: a meta-analysis.Epidemiology and infection · 2015Pooled it
- Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis.BMC medical genetics · 2014Pooled it
- Quantitative analysis of the association between interleukin-10 1082A/G polymorphism and susceptibility to sepsis.Molecular biology reports · 2013Pooled it
- The relationship between expression level and gene polymorphism of inflammatory factors and sepsis risk.Scientific reports · 2025Article
- TheInnate immunity · 2021Article
- A Functional Variant of CXCL16 Is Associated With Predisposition to Sepsis and MODS in Trauma Patients: Genetic Association Studies.Frontiers in genetics · 2021Article
- COVID-19-Associated Coagulopathy and Inflammatory Response: What Do We Know Already and What Are the Knowledge Gaps?Anesthesia and analgesia · 2020Review
- Polygenic Risk Score for Early Prediction of Sepsis Risk in the Polytrauma Screening Cohort.Frontiers in genetics · 2020Article
- Tumor necrosis factor-α -308 G/A polymorphism and risk of sepsis, septic shock, and mortality: an updated meta-analysis.Oncotarget · 2017Article
- Clinical associations of host genetic variations in the genes of cytokines in critically ill patients.Clinical and experimental immunology · 2015Article
- Inhalation injury severity and systemic immune perturbations in burned adults.Annals of surgery · 2013Article
- When grief makes you sick: bereavement induced systemic inflammation is a question of genotype.Brain, behavior, and immunity · 2012Article
- Association of genetic variants in the IRAK-4 gene with susceptibility to severe sepsis.World journal of emergency medicine · 2012Article
- Year in review in Intensive Care Medicine 2010: I. Acute renal failure, outcome, risk assessment and ICU performance, sepsis, neuro intensive care and experimentals.Intensive care medicine · 2011Article
- Genetic polymorphisms and posttraumatic complications.Comparative and functional genomics · 2010Article
- Early pulmonary immune hyporesponsiveness is associated with mortality after burn and smoke inhalation injury.Journal of burn care & research : official publication of the American Burn AssociationArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the clinical relevance of 13 reported common single-nucleotide polymorphisms (SNPs) of cytokine genes in patients with major trauma.
methodsThirteen SNPs in nine key cytokine genes were selected for association study in 308 patients with major trauma on the basis of previous functional or association data. An allele-specific oligonucleotide array was developed and used to genotype 308 patients with major trauma. The clinical relevance of the 13 SNPs was assessed by observation of cytokine production and outcome of trauma patients.
resultsResults from the allele-specific oligonucleotide array indicated that 8 [interleukin-1beta (IL-1beta)/-1470, IL-1beta/-511, IL-1beta/-31, IL-4/-589, IL-6/-572, IL-8/-251, IL-10/-819, and tumor necrosis factor alpha (TNFalpha)/-308] out of the 13 SNPs were associated with respective ex vivo cytokine production by peripheral leukocytes in response to lipopolysaccharide (LPS) stimulation at admission, or risk of development of sepsis or organ dysfunction in major trauma patients. Patients with more than four risk alleles of the eight SNPs had more than 50% sepsis morbidity and more severe organ dysfunction.
conclusionsPolymorphisms of IL-1beta/-1470, IL-1beta/-511, IL-1beta/-31, IL-4/-589, IL-6/-572, IL-8/-251, IL-10/-819, and TNFalpha/-308 are susceptibility loci for the development of sepsis and organ dysfunction in major trauma patients.
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