ArticleJournal of pediatric rehabilitation medicine2009
Puberty, statural growth, and growth hormone release in children with cerebral palsy.
Article in Journal of pediatric rehabilitation medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- A pilot study proposing an algorithm for pubertal induction in cerebral palsy.Journal of pediatric endocrinology & metabolism : JPEM · 2024Trial
- Regional Disparities in Growth Patterns of Children with Cerebral Palsy: A Comparative Analysis of Saudi Arabian, UK, and US Data.Children (Basel, Switzerland) · 2024Article
- Growth patterns in children and adolescents with cerebral palsy from Argentina and Germany.Scientific reports · 2023Article
- 5-year fracture risk among children with cerebral palsy.Pediatric research · 2023Article
- Cardiometabolic Risk and Its Relationship With Visceral Adiposity in Children With Cerebral Palsy.Journal of the Endocrine Society · 2023Article
- Trajectories of medication use and polypharmacy among children with cerebral palsy.Journal of managed care & specialty pharmacy · 2023Article
- Bone health in children with severe cerebral palsy.Frontiers in pediatrics · 2023Article
- 5-year risk of "adult-onset" chronic diseases during childhood and adolescent transitioning for individuals with cerebral palsy.Preventive medicine reports · 2022Article
- Glycine receptor subunit-β-deficiency in a mouse model of spasticity results in attenuated physical performance, growth, and muscle strength.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Growth in infants, children and adolescents with unilateral and bilateral cerebral palsy.Scientific reports · 2022Article
- Preventive Care for Adults With Cerebral Palsy and Other Neurodevelopmental Disabilities: Are We Missing the Point?Frontiers in integrative neuroscience · 2022Article
- Multi-Organ Dysfunction in Cerebral Palsy.Frontiers in pediatrics · 2021Review
- Bone Marrow Fat Physiology in Relation to Skeletal Metabolism and Cardiometabolic Disease Risk in Children With Cerebral Palsy.American journal of physical medicine & rehabilitation · 2018Review
- Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study.International journal of endocrinology · 2017Article
- Assessment of Sexual Maturation Among Girls With Special Needs in Tehran, Iran.Iranian journal of pediatrics · 2016Article
- Automated radiogrammetry is a feasible method for measuring bone quality and bone maturation in severely disabled children.Pediatric radiology · 2016Article
- Paravertebral fascial massage promotes brain development of neonatal rats via the insulin-like growth factor 1 pathway.Neural regeneration research · 2012Article
- Effects of recombinant growth hormone replacement and physical rehabilitation in recovery of gross motor function in children with cerebral palsy.Therapeutics and clinical risk management · 2010Article
- Growth hormone deficiency and cerebral palsy.Therapeutics and clinical risk management · 2010Article
- Multiple Nutritional Deficiencies in Cerebral Palsy Compounding Physical and Functional Impairments.Indian journal of palliative careArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveChildren with cerebral palsy (CP) are smaller than normally growing children.. The association between the growth hormone (GH) axis and growth in children with CP during puberty is unknown. We compared growth and markers of the GH axis in pre-pubertal and pubertal children with moderate to severe CP and without CP over a three-year period. STUDY
designTwenty children with CP, ages 6-18, Gross Motor Function Classification System levels III-V, were compared to a group of sixty-three normally growing children of similar age. Anthropometry, Tanner stage, bone age, and laboratory analyses were performed every six months for three years. Laboratory values included spontaneous overnight GH release, fasting IGF-1 and IGFBP-3. Repeated measures models were used to evaluate interactions among Tanner stage and group (children with CP vs. reference children), taking into account gender, age, and nutritional status.
resultsChildren with CP grew more slowly than those without CP at all Tanner stages (p<0.01). Patterns of IGF-1 and GH secretion in children with CP were similar to those of the reference group; however, the concentrations of IGF-1 (p<0.01) and GH (p<0.01) were lower in girls with CP, with a similar trend for boys (p=0.10 and 0.14, respectively).
conclusionsDiminished circulating IGF-1 and GH concentrations may explain the differences in growth between the two groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.