ArticleJournal of pediatric gastroenterology and nutrition2010
Serum markers may distinguish biliary atresia from other forms of neonatal cholestasis.
Article in Journal of pediatric gastroenterology and nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Development and Validation of Novel Diagnostic Models for Biliary Atresia in a Large Cohort of Chinese Patients.EBioMedicine · 2018Article
- Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia.Science translational medicine · 2017Article
- Biliary atresia: Where do we stand now?World journal of hepatology · 2016Review
- Serum microRNA microarray analysis identifies miR-4429 and miR-4689 are potential diagnostic biomarkers for biliary atresia.Scientific reports · 2016Article
- Diagnostic value of procalcitonin and apo-e in extrahepatic biliary atresia.Iranian journal of pediatrics · 2014Article
- Circulating microRNA is a biomarker of biliary atresia.Journal of pediatric gastroenterology and nutrition · 2012Article
- Digital camera image analysis of faeces in detection of cholestatic jaundice in infants.African journal of paediatric surgery : AJPSArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundBiliary atresia (BA) is the most serious liver disease in infants. Diagnosis currently depends on surgical exploration of the biliary tree. Noninvasive tests that distinguish BA from other types of neonatal liver disease are not available. PATIENTS AND
methodsTo identify potential serum biomarkers that classify children with neonatal cholestasis, we performed 2-dimensional difference gel electrophoresis, statistical analysis, and tandem mass spectrometry using serum samples from 19 infants with BA and 19 infants with non-BA neonatal cholestasis.
resultsEleven potential serum biomarkers were found that could in combination classify children with neonatal cholestasis.
conclusionsAlthough no single biomarker or imaging test adequately distinguishes BA from other types of neonatal cholestasis, combinations of biomarkers, imaging tests, and noninvasive clinical criteria should be further explored as potential tests for rapid and accurate diagnosis of BA.
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Registered trials
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