ArticleJournal of hypertension2010
Genome-wide case/control studies in hypertension: only the 'tip of the iceberg'.
Article in Journal of hypertension, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Mathematical modelling of the influence ofHeliyon · 2024Article
- Genetics of Hypertension in African Americans and Others of African Descent.International journal of molecular sciences · 2019Review
- A Review of the Genetics of Hypertension with a Focus on Gene-Environment Interactions.Current hypertension reports · 2017Review
- Association of a SNP in SLC35F3 Gene with the Risk of Hypertension in a Chinese Han Population.Frontiers in genetics · 2016Article
- CYP17A1 and Blood Pressure Reactivity to Stress in Adolescence.International journal of hypertension · 2015Article
- Genetic implication of a novel thiamine transporter in human hypertension.Journal of the American College of Cardiology · 2014Article
- The utility of copy number variation (CNV) in studies of hypertension-related left ventricular hypertrophy (LVH): rationale, potential and challenges.Molecular cytogenetics · 2013Article
- The role of SNP-loop diuretic interactions in hypertension across ethnic groups in HyperGEN.Frontiers in genetics · 2013Article
- Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets.European journal of human genetics : EJHG · 2012Article
- Autonomic and hemodynamic origins of pre-hypertension: central role of heredity.Journal of the American College of Cardiology · 2012Article
- Beyond genome-wide association studies: new strategies for identifying genetic determinants of hypertension.Current hypertension reports · 2011Review
- Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans.PloS one · 2010Article
- Common charge-shift mutation Glu65Lys in K+ channel β₁-Subunit KCNMB1: pleiotropic consequences for glomerular filtration rate and progressive renal disease.American journal of nephrology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Recent advances in genome technology have enabled genome-wide searching for disease predisposition loci, using dense SNP and haplotype maps. Over the past year, such approaches have yielded positive results in human hypertension. Here we outline factors underlying the rationale for the approach and consider reasons for false positive and negative results. Although the approach has yielded positive results, typically the trait-associated loci explain only a small fraction of the heritable fraction of trait variance. Finally, we consider alternative approaches and emerging strategies to probe the role of heredity in control of blood pressure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.