ArticleJournal of hypertension2010
Linkage of angiotensinogen gene polymorphisms with hypertension in a sibling study of Hong Kong Chinese.
Article in Journal of hypertension, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes.Molecular biology reports · 2014Pooled it
- Summary of Known Genetic and Epigenetic Modification Contributed to Hypertension.International journal of hypertension · 2023Review
- Association between ACE and AGT polymorphism and cardiovascular risk in acromegalic patients.Pituitary · 2017Article
- Association of angiotensinogen gene SNPs and haplotypes with risk of hypertension in eastern Indian population.Clinical hypertension · 2017Article
- Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes.Genes & nutrition · 2015Article
- Gender specific association of RAS gene polymorphism with essential hypertension: a case-control study.BioMed research international · 2014Article
- Association of the angiotensinogen gene polymorphism with atherosclerosis and its risk traits in the Saudi population.BMC cardiovascular disorders · 2013Article
- Association between the M235T polymorphism of the AGT gene and cytokines in patients with hypertension.Experimental and therapeutic medicine · 2012Article
- Article
- A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits.PloS one · 2012Article
- Genetic variants in the renin-angiotensin system and blood pressure reactions to the cold pressor test.Journal of hypertension · 2010Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveThe angiotensinogen gene has been linked with human essential hypertension in whites but the relationship in Asian populations has been less consistent. This study aimed to examine genetic associations between hypertension and the M235T, T174M, and G-217A polymorphisms of the angiotensinogen gene in Chinese siblings.
methodsWe studied members of 126 families with a hypertensive proband, including 434 siblings, of which 178 were hypertensive. Parental history of hypertension was recorded. The M235T, T174M, and G-217A polymorphisms were examined using a microarray method, validated by sequencing. The transmission disequilibrium test was applied to identify whether the genetic polymorphism loci were related to hypertension. Haplotype analysis of the combined polymorphisms was applied using the TRANSMIT program. Linkage study was conducted by applying the affected pedigree member method.
resultsA significant overtransmission was observed for the T235 allele at the M235T polymorphism and hypertension (chi2 = 4.41, P = 0.036) but not for the T174M and G-217A polymorphisms. The haplotype analysis showed a significant association with the haplotypes of paired markers (T174 and T235) with chi2 value of 8.131 (P = 0.004; global test chi2 = 9.131, P = 0.028). Linkage between M235T and hypertension was detected (T = -2.25, P = 0.019), and a tendency for linkage with central obesity-related hypertension was found for the M235T and T174M polymorphisms (P = 0.0087 and P = 0.01).
conclusionThe M235T and T174M variants, especially the T235 allele, contribute to an increased risk of hypertension in these Chinese patients.
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