ArticleGenetics2010
Nonallelic gene conversion in the genus Drosophila.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Low-input PacBio sequencing generates high-quality individual fly genomes and characterizes mutational processes.Nature communications · 2024Article
- Article
- Positively selected genes in the hoary bat (PeerJ · 2022Article
- Comparative analysis of transposable elements provides insights into genome evolution in the genus Camelus.BMC genomics · 2021Article
- Recurrent gene co-amplification on Drosophila X and Y chromosomes.PLoS genetics · 2019Article
- LTR Retrotransposons Show Low Levels of Unequal Recombination and High Rates of Intraelement Gene Conversion in Large Plant Genomes.Genome biology and evolution · 2017Article
- Role of Ectopic Gene Conversion in the Evolution of aGenetics · 2017Article
- Rapid Functional and Sequence Differentiation of a Tandemly Repeated Species-Specific Multigene Family in Drosophila.Molecular biology and evolution · 2017Article
- Article
- Sequencing, assembling, and correcting draft genomes using recombinant populations.G3 (Bethesda, Md.) · 2014Article
- Gene conversion yields novel gene combinations in paralogs of GOT1 in the copepod Tigriopus californicus.BMC evolutionary biology · 2013Article
- Inferring the history of interchromosomal gene transposition in Drosophila using n-dimensional parsimony.Genetics · 2012Article
- Conversion events in gene clusters.BMC evolutionary biology · 2011Article
- Intralocus sexual conflict resolved through gene duplication.Trends in ecology & evolution · 2011Article
- Article
- Article
- Genomic sequence around butterfly wing development genes: annotation and comparative analysis.PloS one · 2011Article
- Analyses of nuclearly encoded mitochondrial genes suggest gene duplication as a mechanism for resolving intralocus sexually antagonistic conflict in Drosophila.Genome biology and evolution · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonallelic gene conversion has been proposed as a major force in homogenizing the sequences of paralogous genes. In this work, we investigate the extent and characteristics of gene conversion among gene families in nine species of the genus Drosophila. We carried out a genome-wide study of 2855 gene families (including 17,742 genes) and determined that conversion events involved 2628 genes. The proportion of converted genes ranged across species from 1 to 9% when paralogs of all ages were included. Although higher levels of gene conversion were found among young gene duplicates, at most 1-2% of the coding sequences of these duplicates were affected by conversion. Using a second approach relying on gene family size changes and gene-tree/species-tree reconciliation methods, we estimate that only 1-15% of gene trees are misled by gene conversion, depending on the lineage considered. Several features of paralogous genes correlate with gene conversion, such as intra-/interchromosomal location, level of nucleotide divergence, and GC content, although we found no definitive evidence for biased substitution patterns. After considering species-specific differences in the age and distance between paralogs, we found a highly significant difference in the amount of gene conversion among species. In particular, members of the melanogaster group showed the lowest proportion of converted genes. Our data therefore suggest underlying differences in the mechanistic basis of gene conversion among species.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.