ArticleGenetics2010
Muller's ratchet and the degeneration of the Drosophila miranda neo-Y chromosome.
Article in Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis reveals that genes regulated by the Y chromosome in Drosophila melanogaster are preferentially localized to repressive chromatin.Genome biology and evolution · 2013Pooled it
- A gene-based model of fitness and its implications for genetic variation: linkage disequilibrium.Genetics · 2025Article
- HJ Muller and the Relationship Between Sex Chromosome Degeneration and the Evolution of Dosage Compensation.Genome biology and evolution · 2025Review
- A gene-based model of fitness and its implications for genetic variation: Linkage disequilibrium.bioRxiv : the preprint server for biology · 2025Article
- Evidence for evolution of a new sex chromosome within the haploid-dominant Marchantiales plant lineage.Journal of integrative plant biology · 2025Article
- A model of Hill-Robertson interference caused by purifying selection in a nonrecombining genome.Genetics · 2025Article
- Evolution, Inheritance, and Strata Formation of the W Chromosome in Duck (Anas platyrhynchos).Genome biology and evolution · 2023Article
- Effects of Selection at Linked Sites on Patterns of Genetic Variability.Annual review of ecology, evolution, and systematics · 2021Article
- The timing of genetic degeneration of sex chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Extreme Y chromosome polymorphism corresponds to five male reproductive morphs of a freshwater fish.Nature ecology & evolution · 2021Article
- YY males of the dioecious plant Mercurialis annua are fully viable but produce largely infertile pollen.The New phytologist · 2019Article
- Degenerative Expansion of a Young Supergene.Molecular biology and evolution · 2019Article
- Role of recombination and faithfulness to partner in sex chromosome degeneration.Scientific reports · 2018Article
- Article
- Background selection as null hypothesis in population genomics: insights and challenges fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- The on-again, off-again relationship between mitochondrial genomes and species boundaries.Molecular ecology · 2017Review
- Article
- Analyses between Reproductive Behavior, Genetic Diversity andFrontiers in plant science · 2016Article
- The evolution of sex: A new hypothesis based on mitochondrial mutational erosion: Mitochondrial mutational erosion in ancestral eukaryotes would favor the evolution of sex, harnessing nuclear recombination to optimize compensatory nuclear coadaptation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- The Evolutionary Tempo of Sex Chromosome Degradation in Carica papaya.Journal of molecular evolution · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since its formation about 1.75 million years ago, the Drosophila miranda neo-Y chromosome has undergone a rapid process of degeneration, having lost approximately half of the genes that it originally contained. Using estimates of mutation rates and selection coefficients for loss-of-function mutations, we show that the high rate of accumulation of these mutations can largely be explained by Muller's ratchet, the process of stochastic loss of the least-loaded mutational class from a finite, nonrecombining population. We show that selection at nonsynonymous coding sites can accelerate the process of gene loss and that this effect varies with the number of genes still present on the degenerating neo-Y chromosome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.