ArticleProceedings of the National Academy of Sciences of the United States of America2010
Superheating of ice crystals in antifreeze protein solutions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 139 citations in OpenAlex.
- Temperature and Pressure Shaped the Evolution of Antifreeze Proteins in Polar and Deep Sea Zoarcoid Fishes.Molecular biology and evolution · 2025Article
- How to measure the activity of antifreeze proteins?Biophysical reviews · 2025Review
- Atomistic Insights into the Chain-Length-Dependent Antifreeze Activity of Oligoprolines.Biomacromolecules · 2025Article
- Functional Genomics of a Collection of Gammaproteobacteria Isolated from Antarctica.Marine drugs · 2024Article
- Extended Temperature Range of the Ice-Binding Protein Activity.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- The Nanoliter Osmometer: Thermal Hysteresis Measurement.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- Subzero Nonfreezing Hypothermia with Insect Antifreeze Protein Dramatically Improves Survival Rate of Mammalian Cells.International journal of molecular sciences · 2021Article
- High Water Density at Non-Ice-Binding Surfaces Contributes to the Hyperactivity of Antifreeze Proteins.The journal of physical chemistry letters · 2021Article
- Polymer Self-Assembly Induced Enhancement of Ice Recrystallization Inhibition.Journal of the American Chemical Society · 2021Article
- Can Halophilic and Psychrophilic Microorganisms Modify the Freezing/Melting Curve of Cold Salty Solutions? Implications for Mars Habitability.Astrobiology · 2020Article
- An Ice-Binding Protein from an Antarctic Ascomycete Is Fine-Tuned to Bind to Specific Water Molecules Located in the Ice Prism Planes.Biomolecules · 2020Article
- Fish-Derived Antifreeze Proteins and Antifreeze Glycoprotein Exhibit a Different Ice-Binding Property with Increasing Concentration.Biomolecules · 2020Article
- Ice Binding Proteins: Diverse Biological Roles and Applications in Different Types of Industry.Biomolecules · 2020Review
- Ice-binding proteins and the applicability and limitations of the kinetic pinning model.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019Article
- The physics and chemistry of ice.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019Article
- Kinetic inhibition effect of Type I and III antifreeze proteins on unidirectional tetrahydrofuran hydrate crystal growth.RSC advances · 2019Article
- Ice recrystallization is strongly inhibited when antifreeze proteins bind to multiple ice planes.Scientific reports · 2019Article
- Combined molecular dynamics and neural network method for predicting protein antifreeze activity.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Polypentagonal ice-like water networks emerge solely in an activity-improved variant of ice-binding protein.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
It has been argued that for antifreeze proteins (AFPs) to stop ice crystal growth, they must irreversibly bind to the ice surface. Surface-adsorbed AFPs should also prevent ice from melting, but to date this has been demonstrated only in a qualitative manner. Here we present the first quantitative measurements of superheating of ice in AFP solutions. Superheated ice crystals were stable for hours above their equilibrium melting point, and the maximum superheating obtained was 0.44 degrees C. When melting commenced in this superheated regime, rapid melting of the crystals from a point on the surface was observed. This increase in melting temperature was more appreciable for hyperactive AFPs compared to the AFPs with moderate antifreeze activity. For each of the AFP solutions that exhibited superheating, the enhancement of the melting temperature was far smaller than the depression of the freezing temperature. The present findings clearly show that AFPs adsorb to ice surfaces as part of their mechanism of action, and this absorption leads to protection of ice against melting as well as freezing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.