ArticleThe Journal of clinical endocrinology and metabolism2010
Amount of bone loss in relation to time around the final menstrual period and follicle-stimulating hormone staging of the transmenopause.
Article in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed.
- Trial
- FSH suppression does not affect bone turnover in eugonadal men.The Journal of clinical endocrinology and metabolism · 2014Trial
- Is Follicle-Stimulating Hormone (FSH) Misnamed? Rethinking Its Role in Menopause as a Systemic Regulator of Bone, Brain, Metabolism, and Aging.Journal of clinical medicine · 2026Review
- Article
- Trajectories of areal bone mineral density significantly differ by patterning of femoral neck area and bone mineral content across the menopausal transition.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Femoral neck width is associated with unique trajectories of age-related hip structural changes and fracture risk within populations of adult women and men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Reversal of Bone Mineral Density Loss Through Lifestyle Changes: A Case Report.American journal of lifestyle medicine · 2025Article
- Altered extracellular matrix and mechanotransduction gene expression in rat bone tissue following long-term estrogen deficiency.JBMR plus · 2024Article
- KIT in oocytes: a key factor for oocyte survival and reproductive lifespan.EBioMedicine · 2024Article
- FSH and ApoE4 contribute to Alzheimer's disease-like pathogenesis via C/EBPβ/δ-secretase in female mice.Nature communications · 2023Article
- Longitudinal changes in bone mineral density during perimenopausal transition: the Vietnam Osteoporosis Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Article
- Treating menopause - MHT and beyond.Nature reviews. Endocrinology · 2022Review
- Recent advances in prophylactics and treatment of osteoporosis.Przeglad menopauzalny = Menopause review · 2022Review
- Changes in Bone Mineral Density and Serum Lipids across the First Postpartum Year: Effect of Aerobic Fitness and Physical Activity.Nutrients · 2022Article
- Soy Isoflavones and Bone Health: Focus on the RANKL/RANK/OPG Pathway.BioMed research international · 2022Review
- Age-Related Changes in Bone Density, Microarchitecture, and Strength in Postmenopausal Black and White Women: The SWAN Longitudinal HR-pQCT Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Article
- FSH modulated cartilage ECM metabolism by targeting the PKA/CREB/SOX9 pathway.Journal of bone and mineral metabolism · 2021Article
- Identification and Functional Characterization of Metabolites for Bone Mass in Peri- and Postmenopausal Chinese Women.The Journal of clinical endocrinology and metabolism · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND AND
objectiveThe objective of the study was to describe bone loss rates across the transmenopause related to FSH staging and the final menstrual period (FMP). DESIGN AND
settingThis was a population-based cohort of 629 women (baseline age 24-44 yr) with annual data points over 15 yr. MEASUREMENTS: Measures were bone mineral density (BMD), FSH to define four FSH stages, and menstrual bleeding cessation to define the FMP. Bone loss rates were reported by obesity status.
resultsAnnualized rates of lumbar spine bone loss began in FSH stage 3, which occurs approximately 2 yr prior to the FMP (1.67%/yr); bone loss continued into FSH stage 4 (1.21%/yr). Mean spine BMD in FSH stage 4 was 6.4% less than spine BMD value in FSH stage 1. Annualized rates of femoral neck (FN) bone loss began in FSH stage 3 (0.55%/yr) and continued into FSH stage 4 (0.72%/yr). The FN difference between mean values in FSH stage 1 and FSH stage 4 was 5%. Annualized rates of spine bone loss in the 2 yr prior to the FMP were 1.7%/yr, 3.3%/yr in the 2 yr after the FMP, and 1.1%/yr in the 2- to 7-yr period after the FMP. Nonobese women had lower BMD levels and greater bone loss rates.
conclusionsSpine and FN bone loss accelerates in FSH stage 3. Bone loss also began to accelerate 2 yr before the FMP with the greatest loss occurring in the 2 yr after the FMP. Bone loss rates in both spine and FN BMD were greater in nonobese women than obese women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.