Evidence map›Paper›PMID 20215141›Full record

ArticleAnnals of the rheumatic diseases2010

Genetic association between methyl-CpG binding protein 2 (MECP2) and primary Sjogren's syndrome.

Beth L Cobb, Yiping Fei, Roland Jonsson, Anne Isine Bolstad, Johan G Brun, Maureen Rischmueller, Susan E Lester, Torsten Witte, Gabor Illei, Michael Brennan and 4 more

Abstract readLetter
In one paragraph

Article in Annals of the rheumatic diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Genetics and epigenetics in primary Sjögren's syndrome.Rheumatology (Oxford, England) · 2021
    Review
  7. Article
  8. Cortisol profiles and clinical severity in MECP2 duplication syndrome.Journal of neurodevelopmental disorders · 2020
    Article
  9. Article
  10. Article
  11. Update on Pathogenesis of Sjogren's Syndrome.Current rheumatology reviews · 2017
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  17. Article
  18. Article
  19. New insight on the Xq28 association with systemic sclerosis.Annals of the rheumatic diseases · 2013
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Beth L Cobb
Yiping Fei
Roland Jonsson
Anne Isine Bolstad
Johan G Brun
Maureen Rischmueller
Susan E Lester
Torsten Witte
Gabor Illei
Michael Brennan
Simon Bowman
Kathy L Moser
John B Harley
Amr H Sawalha

Funding

Clinical Investigations of Sjogren's SyndromeZIADE000704 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI WARNER, BLAKE · 2009 to 2025
$22.3M
THE EFFECTS OF ERK PATHWAY INHIBITION ON DNA METHYLATION IN SLEP20RR015577 · NCRR · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI CENTOLA, MICHAEL B · 2000 to 2009
$21.5M
VALIDATING NOVEL GENES IMPLICATED IN LEUKOCYTE CHEMOTAXISP20RR020143 · NCRR · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI KAUFMAN, KENNETH M · 2004 to 2011
$21.0M
SNP Confirmation and High Throughput Genotyping CoreP30AR053483 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI CHAKRAVARTY, ELIZA F · 2007 to 2017
$6.7M
Pre-Clinical Studies to Identify SLE Therapeutic TargetsU19AI082714 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI JAMES, JUDITH A · 2009 to 2018
$6.2M
Genetic Association in Sjogren's SyndromeR01DE015223 · NIDCR · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI HARLEY, JOHN BARKER · 2004 to 2008
$1.9M
IL-21 polymorphisms in systemic lupus erythematosusR03AI076729 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI SAWALHA, AMR H · 2008 to 2009
$126k
Intramural NIH HHSNCRR NIH HHS P20 RR015577NCRR NIH HHS P20-RR015577NCRR NIH HHS P20 RR020143NCRR NIH HHS P20-RR020143NIAID NIH HHS R03 AI076729NIAID NIH HHS R03AI076729NIAID NIH HHS U19 AI082714NIAMS NIH HHS P30 AR053483NIAMS NIH HHS P30-AR053483NIDCR NIH HHS DE015223NIDCR NIH HHS R01 DE015223
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cohort StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseHumansMaleMethyl-CpG-Binding Protein 2Sjogren's SyndromeMECP2 protein, humanMethyl-CpG-Binding Protein 2

Identifiers

PMID20215141
PMCPMC2920370

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.