ArticleCritical care (London, England)2010
Preadmission statin use and one-year mortality among patients in intensive care - a cohort study.
Article in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Pre-morbid statin use and mortality in trauma: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2026Pooled it
- Bias in observational studies of prevalent users: lessons for comparative effectiveness research from a meta-analysis of statins.American journal of epidemiology · 2012Pooled it
- Propensity scores in intensive care and anaesthesiology literature: a systematic review.Intensive care medicine · 2010Pooled it
- Association between statin therapy and outcomes in critically ill patients: a nested cohort study.BMC clinical pharmacology · 2011Trial
- Association of statin use with 28-day mortality in the Medical Information Mart for Intensive Care IV database: a retrospective cohort study.Journal of thoracic disease · 2025Article
- Effects of statins on the incidence and outcomes of acute kidney injury in critically ill patients: a systematic review and meta-analysis.Archives of medical science : AMS · 2023Review
- Prior statin therapy and mortality among critically ill patients: a systemic review and meta-analysis of cohort studies.Annals of translational medicine · 2020Review
- Lipid profile and statin use in critical care setting: implications for kidney outcome.Einstein (Sao Paulo, Brazil) · 2019Article
- The Danish Intensive Care Database.Clinical epidemiology · 2016Review
- Pre-existing atrial fibrillation and risk of arterial thromboembolism and death in intensive care unit patients: a population-based cohort study.Critical care (London, England) · 2015Article
- Are there any benefits from statin treatment for the septic patient?Current atherosclerosis reports · 2014Review
- Preadmission metformin use and mortality among intensive care patients with diabetes: a cohort study.Critical care (London, England) · 2013Article
- Statins in the critically ill.Annals of intensive care · 2012Article
- In the critically ill patient, diabetes predicts mortality independent of statin therapy but is not associated with acute lung injury: a cohort study.Critical care medicine · 2012Article
- Do aspirin and other antiplatelet drugs reduce the mortality in critically ill patients?Thrombosis · 2012Article
- The immune response: targets for the treatment of severe sepsis.International journal of inflammation · 2012Article
- Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome.Critical care medicine · 2011Article
- Statins in candidemia: clinical outcomes from a matched cohort study.BMC infectious diseases · 2010Article
- Statins for acutely hospitalized patients: randomized controlled trials are long overdue.Critical care (London, England) · 2010Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionStatins reduce risk of cardiovascular events and have beneficial pleiotropic effects; both may reduce mortality in critically ill patients. We examined whether statin use was associated with risk of death in general intensive care unit (ICU) patients.
methodsCohort study of 12,483 critically ill patients > 45 yrs of age with a first-time admission to one of three highly specialized ICUs within the Aarhus University Hospital network, Denmark, between 2001 and 2007. Statin users were identified through population-based prescription databases. We computed cumulative mortality rates 0-30 days and 31-365 days after ICU admission and mortality rate ratios (MRRs), using Cox regression analysis controlling for potential confounding factors (demographics, use of other cardiovascular drugs, comorbidity, markers of social status, diagnosis, and surgery).
results1882 (14.3%) ICU patients were current statin users. Statin users had a reduced risk of death within 30 days of ICU admission [users: 22.1% vs. non-users 25.0%; adjusted MRR = 0.76 (95% confidence interval (CI): 0.69 to 0.86)]. Statin users also had a reduced risk of death within one year after admission to the ICU [users: 36.4% vs. non-users 39.9%; adjusted MRR = 0.79 (95% CI: 0.73 to 0.86)]. Reduced risk of death associated with current statin use remained robust in various subanalyses and in an analysis using propensity score matching. Former use of statins and current use of non-statin lipid-lowering drugs were not associated with reduced risk of death.
conclusionsPreadmission statin use was associated with reduced risk of death following intensive care. The associations seen could be a pharmacological effect of statins, but unmeasured differences in characteristics of statin users and non-users cannot be entirely ruled out.
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