ArticleTraffic (Copenhagen, Denmark)2010
Regulation of tight junction assembly and epithelial polarity by a resident protein of apical endosomes.
Article in Traffic (Copenhagen, Denmark), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Disruption of pulmonary microvascular endothelial barrier by dysregulated claudin-8 and claudin-4: uncovered mechanisms in porcine reproductive and respiratory syndrome virus infection.Cellular and molecular life sciences : CMLS · 2024Article
- Artemisinin analog SM934 alleviates epithelial barrier dysfunctionFrontiers in pharmacology · 2022Article
- Proliferation in the developing intestine is regulated by the endosomal protein Endotubin.Developmental biology · 2021Article
- Blood-Bile Barrier: Morphology, Regulation, and Pathophysiology.Gene expression · 2019Review
- Roles of Membrane and Vesicular Traffic in Regulation of the Hippo Pathway.Frontiers in cell and developmental biology · 2019Review
- The Endosomal Protein Endotubin Is Required for Enterocyte Differentiation.Cellular and molecular gastroenterology and hepatology · 2018Article
- Formation of Giant Lysosome in Neonatal Ileal Enterocytes Requires Endotubin.Cellular and molecular gastroenterology and hepatology · 2018Article
- Receptor-Mediated Endocytosis in the Proximal Tubule.Annual review of physiology · 2017Review
- Postnatal regulation of MAMDC4 in the porcine intestinal epithelium is influenced by bacterial colonization.Physiological reports · 2016Article
- Par3 regulates invasion of pancreatic cancer cells via interaction with Tiam1.Clinical and experimental medicine · 2016Article
- Private rare deletions in SEC16A and MAMDC4 may represent novel pathogenic variants in familial axial spondyloarthritis.Annals of the rheumatic diseases · 2016Article
- Endosomal regulation of contact inhibition through the AMOT:YAP pathway.Molecular biology of the cell · 2015Article
- Bile acids as metabolic regulators.Current opinion in gastroenterology · 2015Review
- Diet1 is a regulator of fibroblast growth factor 15/19-dependent bile acid synthesis.Digestive diseases (Basel, Switzerland) · 2015Article
- Regulation of bile acid homeostasis by the intestinal Diet1-FGF15/19 axis.Current opinion in lipidology · 2014Review
- Novel regulator of enterohepatic bile acid signaling protects against hypercholesterolemia.Cell metabolism · 2013Article
- Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.Cell metabolism · 2013Article
- Article
- Time-resolved quantitative proteome analysis of in vivo intestinal development.Molecular & cellular proteomics : MCP · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The establishment of tight junctions and cell polarity is an essential process in all epithelia. Endotubin is an integral membrane protein found in apical endosomes of developing epithelia when tight junctions and epithelial polarity first arise. We found that the disruption of endotubin function in cells in culture by siRNA or overexpression of the C-terminal cytoplasmic domain of endotubin causes defects in organization and function of tight junctions. We observe defects in localization of tight junction proteins, reduced transepithelial resistance, increased lanthanum penetration between cells and reduced ability of cells to form cysts in three-dimensional culture. In addition, in cells overexpressing the C-terminal domain of endotubin, we observe a delay in re-establishing the normal distribution of endosomes after calcium switch. These results suggest that endotubin regulates trafficking of polarity proteins and tight junction components out of the endosomal compartment, thereby providing a critical link between a resident protein of apical endosomes and tight junctions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.