Evidence map›Paper›PMID 20214448›Full record

ArticleTissue engineering. Part A2010

Tumor engineering: the other face of tissue engineering.

Cyrus M Ghajar, Mina J Bissell

Abstract read
In one paragraph

Article in Tissue engineering. Part A, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Engineering Heterogeneous Tumor Models for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  3. Review
  4. Article
  5. Review
  6. 3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages.International journal of molecular sciences · 2021
    Review
  7. Review
  8. [Decellularized matrix of human fatty liver used for three-dimensional culture of hepatocellular carcinoma cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019
    Article
  9. Review
  10. Decellularized Extracellular Matrix for Cancer Research.Materials (Basel, Switzerland) · 2019
    Review
  11. Article
  12. Relevance of 3d culture systems to study osteosarcoma environment.Journal of experimental & clinical cancer research : CR · 2018
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics.Virchows Archiv : an international journal of pathology · 2015
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cyrus M GhajarLife Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720-8206, USA. cmghajar@lbl.gov
Mina J Bissell

Funding

Systems-Based Predictions of Responses to Cancer TherapyU54CA112970 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI SPELLMAN, PAUL T. · 2004 to 2014
$27.1M
Role of Metalloproteinases in Mammary Gland RemodelingR01CA057621 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WERB, ZENA · 1993 to 2017
$9.0M
Definition of the Microenvironment in Breast CancerR01CA064786 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI BISSELL, MINA · 1995 to 2020
$6.1M
Bioengineering 3-D Models for Organ-Specific Cancer Therapy in Lung and BreastU54CA126552 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI BISSELL, MINA · 2006 to 2010
$2.2M
Definition of Microenvironment in Breast CancerR37CA064786 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI BISSELL, MINA · 2009 to 2013
$2.0M
NCI NIH HHS R01 CA057621NCI NIH HHS R01CA057621NCI NIH HHS R01 CA064786NCI NIH HHS R01CA064786NCI NIH HHS R37 CA064786NCI NIH HHS U54 CA112970NCI NIH HHS U54CA112970NCI NIH HHS U54 CA126552NCI NIH HHS U54CA126552
6 · The paper itself

Abstract

Advances in tissue engineering have been accomplished for years by employing biomimetic strategies to provide cells with aspects of their original microenvironment necessary to reconstitute a unit of both form and function for a given tissue. We believe that the most critical hallmark of cancer is loss of integration of architecture and function; thus, it stands to reason that similar strategies could be employed to understand tumor biology. In this commentary, we discuss work contributed by Fischbach-Teschl and colleagues to this special issue of Tissue Engineering in the context of 'tumor engineering', that is, the construction of complex cell culture models that recapitulate aspects of the in vivo tumor microenvironment to study the dynamics of tumor development, progression, and therapy on multiple scales. We provide examples of fundamental questions that could be answered by developing such models, and encourage the continued collaboration between physical scientists and life scientists not only for regenerative purposes, but also to unravel the complexity that is the tumor microenvironment.

Indexed as

AnimalsExtracellular MatrixHealth Care CostsHumansIntercellular Signaling Peptides and ProteinsNeoplasmsTissue EngineeringIntercellular Signaling Peptides and Proteins

Identifiers

PMID20214448
PMCPMC2947934

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.