ArticleJournal of biomedical materials research. Part A2010
Surveillance of systemic trafficking of macrophages induced by UHMWPE particles in nude mice by noninvasive imaging.
Article in Journal of biomedical materials research. Part A, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- The Role of the Innate Immune System in Wear Debris-Induced Inflammatory Peri-Implant Osteolysis in Total Joint Arthroplasty.Bioengineering (Basel, Switzerland) · 2022Review
- Inflammation and Bone Repair: From Particle Disease to Tissue Regeneration.Frontiers in bioengineering and biotechnology · 2019Review
- The biological response to orthopedic implants for joint replacement. II: Polyethylene, ceramics, PMMA, and the foreign body reaction.Journal of biomedical materials research. Part B, Applied biomaterials · 2017Review
- UHMWPE wear particles and dendritic cells promote osteoclastogenesis of RAW264.7 cells through RANK-activated NF-κB/MAPK/AKT pathways.International journal of clinical and experimental pathology · 2017Article
- Chemokines Associated with Pathologic Responses to Orthopedic Implant Debris.Frontiers in endocrinology · 2017Review
- Aging, inflammation, stem cells, and bone healing.Stem cell research & therapy · 2016Review
- Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement.Journal of the Royal Society, Interface · 2014Review
- The pathology of orthopedic implant failure is mediated by innate immune system cytokines.Mediators of inflammation · 2014Review
- Macrophage polarization in response to wear particles in vitro.Cellular & molecular immunology · 2013Article
- Macrophages-Key cells in the response to wear debris from joint replacements.Journal of biomedical materials research. Part A · 2013Review
- The basic science of periprosthetic osteolysis.Instructional course lectures · 2013Article
- Exogenous MC3T3 preosteoblasts migrate systemically and mitigate the adverse effects of wear particles.Tissue engineering. Part A · 2012Article
- Effect of a CCR1 receptor antagonist on systemic trafficking of MSCs and polyethylene particle-associated bone loss.Biomaterials · 2012Article
- Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2012Article
- The role of TLR and chemokine in wear particle-induced aseptic loosening.Journal of biomedicine & biotechnology · 2012Review
- Role of polyethylene particles in peri-prosthetic osteolysis: A review.World journal of orthopedics · 2011Article
- New animal models of wear-particle osteolysis.International orthopaedics · 2011Review
- The basic science of periprosthetic osteolysis.Instructional course lectures · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Macrophages constitute a major part of the cell response to wear particles produced at articulating and nonarticulating interfaces of joint replacements. This foreign body reaction can result in periprosthetic osteolysis and implant loosening. We demonstrate that ultra-high molecular weight polyethylene (UHMWPE) particles induce systemic trafficking of macrophages by noninvasive in vivo imaging and immunohistochemistry. The distal femora of nude mice were injected with 60 mg/mL UHMWPE suspension or saline alone. Reporter RAW264.7 macrophages that stably expressed the bioluminescent reporter gene and the fluorescence reporter gene were injected intravenously. Bioluminescence imaging was performed using an in vivo imaging system immediately after macrophage injection and at 2-day intervals. Compared with the nonoperated contralateral femora, at day 4, 6, and 8, the bioluminescent signal of femora containing UHMWPE suspension increased 1.30 +/- 0.09-, 2.36 +/- 0.92-, and 10.32 +/- 7.61-fold, respectively. The values at same time points for saline-injected control group were 1.08 +/- 0.07-, 1.14 +/- 0.27-, and 1.14 +/- 0.35-fold, respectively. The relative bioluminescence of the UHMWPE group was higher at all postinjection days and significantly greater than the saline group at day 8 (p < 0.05). Histological analysis confirmed the presence of reporter macrophages within the medullary canal of mice with implanted UHMWPE particles. The presence of UHMWPE particles induced enhanced bone remodeling activity. Clinically relevant UHMWPE particles stimulated the systemic recruitment of macrophages during an early time course using the murine femoral implant model. Interference with systemic macrophage trafficking may potentially mitigate UHMWPE particle-induced periprosthetic osteolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.