ArticleEuropean journal of immunology2010
Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance.
Article in European journal of immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- C1q as a target molecule to treat human disease: What do mouse studies teach us?Frontiers in immunology · 2022Pooled it
- Recent advances into the role of pattern recognition receptors in transplantation.Cellular immunology · 2020Review
- Vitamin D (1,25(OH)The Journal of steroid biochemistry and molecular biology · 2019Article
- Genome-Wide CRISPR Screen Identifies Host Factors Required byFrontiers in cellular and infection microbiology · 2019Article
- Kidney Transplantation: The Challenge of Human Leukocyte Antigen and Its Therapeutic Strategies.Journal of immunology research · 2018Review
- Complement component 3 deficiency prolongs MHC-II disparate skin allograft survival by increasing the CD4(+) CD25(+) regulatory T cells population.Scientific reports · 2016Article
- Radiotherapy: killing with complement.Annals of translational medicine · 2016Article
- SLE-associated risk factors affect DC function.Immunological reviews · 2016Review
- Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation.Journal of leukocyte biology · 2015Article
- Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency.Immunology · 2015Article
- Complement modulation of T cell immune responses during homeostasis and disease.Journal of leukocyte biology · 2014Review
- Complement opsonization of HIV-1 results in decreased antiviral and inflammatory responses in immature dendritic cells via CR3.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis.Clinical and experimental immunology · 2013Article
- The role of complement component 3 (C3) in differentiation of myeloid-derived suppressor cells.Blood · 2013Article
- Article
- Annexin A2 and A5 serve as new ligands for C1q on apoptotic cells.The Journal of biological chemistry · 2012Article
- The role of complement in the early immune response to transplantation.Nature reviews. Immunology · 2012Review
- C1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa.European journal of human genetics : EJHG · 2012Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Complement activation is known to have deleterious effects on organ transplantation. On the other hand, the complement system is also known to have an important role in regulating immune responses. The balance between these two opposing effects is critical in the context of transplantation. Here, we report that female mice deficient in C1q (C1qa(-/-)) or C3 (C3(-/-)) reject male syngeneic grafts (HY incompatible) at an accelerated rate compared with WT mice. Intranasal HY peptide administration, which induces tolerance to syngeneic male grafts in WT mice, fails to induce tolerance in C1qa(-/-) or C3(-/-) mice. The rejection of the male grafts correlated with the presence of HY D(b)Uty-specific CD8(+) T cells. Consistent with this, peptide-treated C1qa(-/-) and C3(-/-) female mice rejecting male grafts exhibited more antigen-specific CD8(+)IFN-gamma(+) and CD8(+)IL-10(+) cells compared with WT females. This suggests that accumulation of IFN-gamma- and IL-10-producing T cells may play a key role in mediating the ongoing inflammatory process and graft rejection. Interestingly, within the tolerized male skin grafts of peptide-treated WT mice, IFN-gamma, C1q and C3 mRNA levels were higher compared to control female grafts. These results suggest that C1q and C3 facilitate the induction of intranasal tolerance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.