Evidence map›Paper›PMID 20213683›Full record

ArticleCancer2010

Occupational sunlight exposure and risk of renal cell carcinoma.

Sara Karami, Paolo Boffetta, Patricia Stewart, Nathaniel Rothman, Katherine L Hunting, Mustafa Dosemeci, Sonja I Berndt, Paul Brennan, Wong-Ho Chow, Lee E Moore

Open access · hybridAbstract read
In one paragraph

Article in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Dietary and circulating vitamin D and risk of renal cell carcinoma: a meta-analysis of observational studies.International braz j urol : official journal of the Brazilian Society of Urology
    Pooled it
  2. Article
  3. A Population-Based Family Case-Control Study of Sun Exposure and Follicular Lymphoma Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Vitamin d pathway genes, diet, and risk of renal cell carcinoma.International journal of endocrinology · 2010
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sara KaramiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. karamis@mail.nih.gov
Paolo Boffetta
Patricia Stewart
Nathaniel Rothman
Katherine L Hunting
Mustafa Dosemeci
Sonja I Berndt
Paul Brennan
Wong-Ho Chow
Lee E Moore
National Institutes of Health · USNational Cancer Institute · USCentre International de Recherche sur le Cancer · FRGeorge Washington University · US

Funding

Studies of Occupational CancerZIACP010120 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI LAN, QING · 2009 to 2025
$34.4M
STUDIES ON OCCUPATIONAL CANCER--EXPOSURES OTHER THAN PESTICIDESZ01CP010120 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI HAYES, RICHARD S · 1996 to 2008
$9.0M
Intramural NIH HHS Z01 CP010120
6 · The paper itself

Abstract

backgroundRecent findings indicate that vitamin D obtained from ultraviolet (UV) exposure may reduce the risk of several different cancers. Vitamin D is metabolized to its active form within the kidney, which is the major organ for vitamin D metabolism and activity. Because both the incidence of renal cell carcinoma (RCC) and the prevalence of vitamin D deficiency have increased over the past few decades, in the current study, the authors explored whether occupational UV exposure was associated with RCC risk.

methodsA hospital-based, case-control study of 1097 patients with RCC (cases) and 1476 controls was conducted in 4 Central and Eastern European countries. Demographic and occupational information was collected to examine the association between occupational UV exposure and RCC risk.

resultsA significant reduction (24%-38%) in the risk of RCC was observed with increasing occupational UV exposure among men who participated in the study. No association between UV exposure and RCC risk was observed among women who participated. When the analyses were stratified by latitude as another estimate of sunlight intensity, a stronger reduction (71%-73%) in the risk of RCC was observed between UV exposure and cancer risk among men who resided at the highest latitudes.

conclusionsThe current results suggested that, among men, there is an inverse association between occupational UV exposure and the risk of RCC. Replication studies are warranted to confirm these results.

Indexed as

Occupational ExposureSunlightAgedCarcinoma, Renal CellCase-Control StudiesFemaleHumansKidney NeoplasmsMaleMiddle AgedRiskSex FactorsVitamin D Deficiency

Identifiers

PMID20213683
PMCPMC2856708
OpenAlexW2072121424

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.