Evidence map›Paper›PMID 20213550›Full record

ReviewSub-cellular biochemistry2010

Protein mediators of sterol transport across intestinal brush border membrane.

J Mark Brown, Liqing Yu

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sub-cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
11.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Association of ABCG5 and ABCG8 Transporters with Sitosterolemia.Advances in experimental medicine and biology · 2024
    Review
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

J Mark BrownDepartment of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Liqing Yu
Wake Forest University · US

Funding

Mechanisms Regulating Non-biliary Fecal Sterol LossR00HL096166 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BROWN, JONATHAN MARK · 2011 to 2013
$733k
Mechanisms Regulating Non-biliary Fecal Sterol LossK99HL096166 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BROWN, JONATHAN MARK · 2009 to 2010
$180k
NHLBI NIH HHS 1K99HL096166-01NHLBI NIH HHS K99 HL096166NHLBI NIH HHS R00 HL096166
6 · The paper itself

Abstract

Dysregulation of cholesterol balance contributes significantly to atherosclerotic cardiovascular disease (ASCVD), the leading cause of death in the United States. The intestine has the unique capability to act as a gatekeeper for entry of cholesterol into the body, and inhibition of intestinal cholesterol absorption is now widely regarded as an attractive non-statin therapeutic strategy for ASCVD prevention. In this chapter we discuss the current state of knowledge regarding sterol transport across the intestinal brush border membrane. The purpose of this work is to summarize substantial progress made in the last decade in regards to protein-mediated sterol trafficking, and to discuss this in the context of human disease.

Indexed as

Intestinal AbsorptionAnimalsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 5ATP Binding Cassette Transporter, Subfamily G, Member 8AzetidinesCholesterolEzetimibeGene Expression RegulationHumansIntracellular Signaling Peptides and ProteinsLipoproteinsMembrane ProteinsMembrane Transport ProteinsMicrovilliModels, AnimalABCG5 protein, humanABCG8 protein, humanATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 5ATP Binding Cassette Transporter, Subfamily G, Member 8AzetidinesCholesterolEzetimibeIntracellular Signaling Peptides and ProteinsLipoproteinsMembrane ProteinsMembrane Transport ProteinsNPC1L1 protein, humanSCARB1 protein, humanScavenger Receptors, Class BSREBP cleavage-activating protein

Identifiers

PMID20213550
PMCPMC3307050
OpenAlexW69033956

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.