ArticleThe journal of headache and pain2010
Frequencies of genetic polymorphisms related to triptans metabolism in chronic migraine.
Article in The journal of headache and pain, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Association Between Polymorphisms of DRD2, COMT, DBH, and MAO-A Genes and Migraine Susceptibility: A Meta-Analysis.Medicine · 2015Pooled it
- Preventive pharmacologic treatments for episodic migraine in adults.Journal of general internal medicine · 2013Pooled it
- Influences of Genetic and Environmental Factors on Chronic Migraine: A Narrative Review.Current pain and headache reports · 2024Review
- Advances in genetics of migraine.The journal of headache and pain · 2019Review
- Genetic and biochemical changes of the serotonergic system in migraine pathobiology.The journal of headache and pain · 2017Review
- Update on Medication-Overuse Headache and Its Treatment.Current treatment options in neurology · 2015Article
- Neural Plasticity in Common Forms of Chronic Headaches.Neural plasticity · 2015Review
- Characterization of CYP1A2, CYP2C19, CYP3A4 and CYP3A5 polymorphisms in South Brazilians.Molecular biology reports · 2014Article
- The omics in migraine.The journal of headache and pain · 2013Review
- Chronic migraine plus medication overuse headache: two entities or not?The journal of headache and pain · 2011Review
- Polymorphism of the Glutamate Transporter Protein EAAT2 and Migraine Transformation into Chronic Daily Headache.Journal of clinical neurology (Seoul, Korea) · 2011Article
- Dispute settlement understanding on the use of Botox in chronic migraine.The journal of headache and pain · 2011Article
- Rehabilitating chronic migraine complicated by medication overuse headaches: how can we prevent migraine relapse?Internal and emergency medicine · 2011Review
- Genetic polymorphisms related to efficacy and overuse of triptans in chronic migraine.The journal of headache and pain · 2010Article
- Chronic migraine: comorbidities, risk factors, and rehabilitation.Internal and emergency medicine · 2010Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic migraine (CM) prevalence ranges around 1-5%. Most of these patients usually treat their acute attacks with triptans, whose efficacy is extremely variable. A genetic basis for migraine is evident and many susceptibility genes have been described, as well as gene polymorphisms possibly implied in therapy response. Several factors could be involved in the evolution of episodic migraine into a chronic form, such as natural history, psychiatric comorbidity, and the individual's response to therapy. During a study aimed at detecting connections between genotype and response to triptans administration, we characterized a CM population for polymorphisms in the genes coding for monoamine oxidase A, g-protein beta 3 and the cytochromes CYP3A4 and CYP1A2. Alleles and genotypes distributions were compared with known frequencies of healthy Caucasian populations. A significant association with CM was found for the long allele of monoamine oxidase A 30 bp VNTR and CYP1A2*1F variant. Such genomic analysis is part of an integrated platform able to evaluate different levels of metabolic pathways of drugs in CM and their influence in the chronicization process.
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Registered trials
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