ArticleInternational journal of colorectal disease2010
Phenotypic diversity in patients with multiple serrated polyps: a genetics clinic study.
Article in International journal of colorectal disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.The American journal of gastroenterology · 2015Guideline
- Tumour spectrum, distinguishing features and management recommendations for NTHL1-associated tumour syndrome: a systematic review.Hereditary cancer in clinical practice · 2025Review
- Management of Serrated Polyps of the Colon.Current treatment options in gastroenterology · 2018Review
- Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management.The American journal of gastroenterology · 2017Review
- Clinical predictors for sessile serrated polyposis syndrome: A case control study.World journal of gastrointestinal endoscopy · 2017Article
- Gastrointestinal tract cancers: Genetics, heritability and germ line mutations.Oncology letters · 2017Article
- The clinical impact of serrated colorectal polyps.Clinical epidemiology · 2017Review
- Type 1 serrated polyposis represents a predominantly female disease with a high prevalence of dysplastic serrated adenomas, without germline mutation in MUTYH, APC, and PTEN genes.United European gastroenterology journal · 2016Article
- Multiple primary colorectal cancer: Individual or familial predisposition?World journal of gastrointestinal oncology · 2015Review
- Serrated polyps and their alternative pathway to the colorectal cancer: a systematic review.Gastroenterology research and practice · 2015Review
- Genetic predisposition to colorectal cancer: where we stand and future perspectives.World journal of gastroenterology · 2014Review
- Extracolonic cancer risk in patients with serrated polyposis syndrome and their first-degree relatives.Familial cancer · 2013Article
- Serrated colon polyps as precursors to colorectal cancer.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2013Article
- Family history of colorectal cancer in BRAF p.V600E-mutated colorectal cancer cases.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management.Journal of gastroenterology · 2013Review
- Multiplicity and molecular heterogeneity of colorectal carcinomas in individuals with serrated polyposis.The American journal of surgical pathology · 2013Article
- Article
- Article
- Serrated polyposis is an underdiagnosed and unclear syndrome: the surgical pathologist has a role in improving detection.The American journal of surgical pathology · 2012Article
- Phenotype and polyp landscape in serrated polyposis syndrome: a series of 100 patients from genetics clinics.The American journal of surgical pathology · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
35 authors at 19 institutions in 5 countries.
Funding
Abstract
objectiveHyperplastic polyposis is a colonic polyposis condition of unknown aetiology. The purpose of this study was to examine the spectrum of phenotypic variation in patients with multiple serrated polyps as a basis for gene discovery.
methodsOne hundred and twenty-six patients with multiple (> or = 5) serrated polyps were recruited to the study. Polyp counts were extracted from histology and colonoscopy reports. Ethnicity was self-reported. Family history of cancer data were derived from pedigrees. Ascertainment status was classified as either index case or identified by screening.
resultsThe average reported polyp count was 39. Patients with highest polyp numbers were more likely to be male (P = 0.02). Colorectal cancer (CRC) was identified in 49 of 119 patients (41%) and 28% of these patients had multiple CRC. Young onset patients had higher polyp numbers (P = 0.03) and were more likely to have their CRC in the distal colon (P = 0.02). CRC was significantly associated with the presence of adenomas (P = 0.03). Patients were divided into moderate polyposis (5-79 serrated polyps) and dense polyposis (80 or more) categories. The dense polyposis category was associated with a lack of family history for CRC (P = 0.034) and male gender (P = 0.014), independent of ascertainment status and recruitment site.
conclusionMultiple serrated polyps were associated with an increased personal risk of CRC. A subset of patients with the highest polyp numbers was more likely to be male and to have no family history of CRC. This result suggests heterogeneous modes of inheritance and has implications for studies investigating the genetic basis of multiple serrated polyps.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.