ArticleWiener klinische Wochenschrift2010
Potential drug-drug interactions and admissions due to drug-drug interactions in patients treated in medical departments.
Article in Wiener klinische Wochenschrift, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Prevalence of clinically manifested drug interactions in hospitalized patients: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Drug-drug interaction software in clinical practice: a systematic review.European journal of clinical pharmacology · 2015Pooled it
- Drug-Related Hospital Visits and Admissions Associated with Laboratory or Physiologic Abnormalities-A Systematic-Review.PloS one · 2013Pooled it
- Predictors of potential clinically harmful drug-drug interactions at the medical wards in the University of Benin Teaching Hospital, Benin City.Clinical and translational science · 2024Article
- Potential Drug-drug Interactions among Hospital Discharge Prescriptions in a Tertiary Care Centre of Nepal: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2022Article
- Predictors of drug-drug interactions of medications prescribed to patients admitted due to suicidal behavior.Heliyon · 2022Article
- Possibility of Multiple Drug-Drug Interactions in Patients Treated with Statins: Analysis of Data from the Japanese Adverse Drug Event Report (JADER) Database and Verification by Animal Experiments.International journal of medical sciences · 2022Article
- Drug-drug interactions in polypharmacy patients: The impact of renal impairment.Current research in pharmacology and drug discovery · 2021Review
- Potential Drug-drug Interactions in Acute Ischemic Stroke Patients at the Neurological Intensive Care Unit.Open medicine (Warsaw, Poland) · 2019Article
- Are patients with a nasally placed feeding tube at risk of potential drug-drug interactions? A multicentre cross-sectional study.PloS one · 2019Article
- Evaluation of Potential Drug-Drug Interactions with Medications Prescribed to Geriatric Patients in a Tertiary Care Hospital.Journal of aging research · 2018Article
- Comparative analysis of three drug-drug interaction screening systems against probable clinically relevant drug-drug interactions: a prospective cohort study.European journal of clinical pharmacology · 2017Article
- Potential drug-drug interactions among hospitalized patients in a developing country.Caspian journal of internal medicine · 2017Article
- Statin drug-drug interactions in a Romanian community pharmacy.Clujul medical (1957) · 2016Article
- Potential drug-drug interactions in hospitalized patients with chronic heart failure and chronic obstructive pulmonary disease.Archives of medical science : AMS · 2014Article
- Differences of Reasons for Alert Overrides on Contraindicated Co-prescriptions by Admitting Department.Healthcare informatics research · 2014Article
- Prevalence of potential drug-drug interactions among internal medicine ward in University of Gondar Teaching Hospital, Ethiopia.Asian Pacific journal of tropical biomedicine · 2014Article
- Article
- Potential drug-drug interactions in prescriptions to patients over 45 years of age in primary care, southern Brazil.PloS one · 2012Article
- Drug-drug interactions and adverse drug reactions: separating the wheat from the chaff.Wiener klinische Wochenschrift · 2010Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdverse drug reactions due to drug-drug interactions (DDIs) are important in drug safety. The aim of this study was to check potential DDIs (pDDIs) on hospital admission and discharge and to evaluate admissions due to DDIs in medical departments of a primary city and tertiary referral hospital.
methodsAge, sex, presence of renal and liver failure, drug information, diagnosis, and urgency and reason for admission were retrospectively recorded in 520 randomly selected patients in medical departments of the University Medical Center Ljubljana. The screening program Drug-Reax was used to check for pDDIs in patients with drug information on both admission and discharge home, and the proportion of patients admitted as the consequence of a DDI was estimated.
resultsOverall, 14.6% (76/520) of patients had incomplete information on drug names in their medical documentation on admission; at the end of treatment 12.5% (52/416) of patients were discharged home with incomplete information on drug names in their discharge letters. A total of 323 patients had complete information on drug names on both admission and discharge and were included in the analysis of pDDIs: 51% (166/323) of patients on admission and 63% (204/323) on discharge had at least one pDDI (P = 0.001). Major pDDIs were found in 13% (41/323) of patients on admission and 18% (59/323) on discharge (P = 0.001). An ACE inhibitor combined with spironolactone was the most common major pDDI, representing 20.0% of all pDDIs on admission and 25.6% on discharge. Among patients with pDDI on admission, 2.4% (4/166) of were admitted because of an ADR caused by a DDI. Overall, 1.2% (4/323) of patients were admitted as the consequence of a DDI.
conclusionsThe information on patient medication on hospital admission and discharge is incomplete. Half of patients on admission and almost two-thirds on discharge had pDDIs. ADRs due to DDIs caused 1.2% of admissions to medical departments in Ljubljana's primary city and tertiary referral hospital.
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