ArticleCellular and molecular life sciences : CMLS2010
Tricellulin forms homomeric and heteromeric tight junctional complexes.
Article in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Dietary supplementation withAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- Virus-associated disruption of mucosal epithelial tight junctions and its role in viral transmission and spread.Tissue barriers · 2021Review
- Tight Junctions as Targets and Effectors of Mucosal Immune Homeostasis.Cellular and molecular gastroenterology and hepatology · 2020Review
- Structural Features of Tight-Junction Proteins.International journal of molecular sciences · 2019Review
- Apoptotic Fragmentation of Tricellulin.International journal of molecular sciences · 2019Article
- Marked differences in tight junction composition and macromolecular permeability among different intestinal cell types.BMC biology · 2018Article
- SUMOylation regulates the intracellular fate of ZO-2.Cellular and molecular life sciences : CMLS · 2017Article
- The intestinal epithelial barrier: a therapeutic target?Nature reviews. Gastroenterology & hepatology · 2017Review
- The Mammalian Blood-Testis Barrier: Its Biology and Regulation.Endocrine reviews · 2015Review
- Molecular genetics of MARVELD2 and clinical phenotype in Pakistani and Slovak families segregating DFNB49 hearing loss.Human genetics · 2015Article
- ILDR1 null mice, a model of human deafness DFNB42, show structural aberrations of tricellular tight junctions and degeneration of auditory hair cells.Human molecular genetics · 2015Article
- Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Gene expression correlations in human cancer cell lines define molecular interaction networks for epithelial phenotype.PloS one · 2014Article
- CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity.Cell communication and signaling : CCS · 2013Article
- Regulation of intestinal epithelial permeability by tight junctions.Cellular and molecular life sciences : CMLS · 2013Review
- Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions.Cell and tissue research · 2013Article
- Modulation of tight junction structure and function by kinases and phosphatases targeting occludin.Journal of biomedicine & biotechnology · 2012Review
- Claudins: control of barrier function and regulation in response to oxidant stress.Antioxidants & redox signaling · 2011Review
- Claudins and tricellulin in fibrolamellar hepatocellular carcinoma.Virchows Archiv : an international journal of pathology · 2011Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sealing of the paracellular cleft by tight junctions is of central importance for epithelia and endothelia to function as efficient barriers between the extracellular space and the inner milieu. Occludin and claudins represent the major tight junction components involved in establishing this barrier function. A special situation emerges at sites where three cells join together. Tricellulin, a recently identified tetraspan protein concentrated at tricellular contacts, was reported to organize tricellular as well as bicellular tight junctions. Here we show that in MDCK cells, the tricellulin C-terminus is important for the basolateral translocation of tricellulin, whereas the N-terminal domain appears to be involved in directing tricellulin to tricellular contacts. In this respect, identification of homomeric tricellulin-tricellulin and of heteromeric tricellulin-occludin complexes extends a previously published model and suggests that tricellulin and occludin are transported together to the edges of elongating bicellular junctions and get separated when tricellular contacts are formed.
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