ArticleMolecular systems biology2010
Precision and scaling in morphogen gradient read-out.
Article in Molecular systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
- Article
- Article
- Quantifying Temperature Compensation of Bicoid Gradients with a Fast T-Tunable Microfluidic Device.Biophysical journal · 2020Article
- Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis.Molecular systems biology · 2018Article
- Mechanisms and Measurements of Scale Invariance of Morphogen Gradients.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Scaling of morphogenetic patterns in reaction-diffusion systems.Journal of theoretical biology · 2016Article
- The organelle of differentiation in embryos: the cell state splitter.Theoretical biology & medical modelling · 2016Review
- Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila.Nature communications · 2015Article
- Pom1 gradient buffering through intermolecular auto-phosphorylation.Molecular systems biology · 2015Article
- Fundamental origins and limits for scaling a maternal morphogen gradient.Nature communications · 2015Article
- Adaptation of the length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large Drosophila melanogaster embryos.Development (Cambridge, England) · 2014Article
- Size-dependent regulation of dorsal-ventral patterning in the early Drosophila embryo.Developmental biology · 2013Article
- Uncovering a dynamic feature of the transcriptional regulatory network for anterior-posterior patterning in the Drosophila embryo.PloS one · 2013Article
- A spatial point pattern analysis in Drosophila blastoderm embryos evaluating the potential inheritance of transcriptional states.PloS one · 2013Article
- Accurate measurements of dynamics and reproducibility in small genetic networks.Molecular systems biology · 2013Article
- The role of Bicoid cooperative binding in the patterning of sharp borders in Drosophila melanogaster.Developmental biology · 2012Article
- The effect of the signalling scheme on the robustness of pattern formation in development.Interface focus · 2012Article
- Improved readout precision of the Bicoid morphogen gradient by early decoding.Journal of biological physics · 2012Article
- Dpp signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc.PLoS biology · 2011Article
Corrections and comments
- Commented on by
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphogen gradients infer cell fate as a function of cellular position. Experiments in Drosophila embryos have shown that the Bicoid (Bcd) gradient is precise and exhibits some degree of scaling. We present experimental results on the precision of Bcd target genes for embryos with a single, double or quadruple dose of bicoid demonstrating that precision is highest at mid-embryo and position dependent, rather than gene dependent. This confirms that the major contribution to precision is achieved already at the Bcd gradient formation. Modeling this dynamic process, we investigate precision for inter-embryo fluctuations in different parameters affecting gradient formation. Within our modeling framework, the observed precision can only be achieved by a transient Bcd profile. Studying different extensions of our modeling framework reveals that scaling is generally position dependent and decreases toward the posterior pole. Our measurements confirm this trend, indicating almost perfect scaling except for anterior most expression domains, which overcompensate fluctuations in embryo length.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.