ReviewNature reviews. Neurology2010
Predicting language outcome and recovery after stroke: the PLORAS system.
Review in Nature reviews. Neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pragmatic Solutions for Stroke Recovery and Improved Quality of Life in Low- and Middle-Income Countries-A Systematic Review.Frontiers in neurology · 2020Pooled it
- Auditory training changes temporal lobe connectivity in 'Wernicke's aphasia': a randomised trial.Journal of neurology, neurosurgery, and psychiatry · 2017Trial
- The right hemisphere supports but does not replace left hemisphere auditory function in patients with persisting aphasia.Brain : a journal of neurology · 2013Trial
- Cortical hierarchy and aphasia severity: the sensorimotor-association gradient modulates lesion effects within language-specific networks.Communications biology · 2026Article
- Exploring Language Recovery Pattern in Persons with Aphasia Across Acute and Sub-Acute Stages.Behavioral sciences (Basel, Switzerland) · 2025Article
- Cortical stimulation predicts language decline following SEEG radiofrequency thermocoagulation.Brain : a journal of neurology · 2025Observational
- Behavioral Clusters and Lesion Distributions in Ischemic Stroke, Based on NIHSS Similarity Network.Journal of healthcare informatics research · 2025Article
- Consensus recommendations for clinical functional MRI applied to language mapping.Aperture neuro · 2025Article
- Brain health operationalized as brain parenchymal fraction impacts stroke severity both in acute phase and 3 months post stroke.Brain communications · 2025Article
- Connectomic stroke lesion measures provide no benefit over basic spatial lesion features in the prognosis of global stroke outcome measures.Brain communications · 2025Article
- The challenge of long-term stroke outcome prediction and how statistical correlates do not imply predictive value.Brain communications · 2025Article
- A preliminary study of white matter disconnections underlying deficits in praxis in left hemisphere stroke patients.Brain structure & function · 2024Article
- Situating word deafness within aphasia recovery: A case report.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Efficacy of a gamified digital therapy for speech production in people with chronic aphasia (iTalkBetter): behavioural and imaging outcomes of a phase II item-randomised clinical trial.EClinicalMedicine · 2024Article
- Using in vivo functional and structural connectivity to predict chronic stroke aphasia deficits.Brain : a journal of neurology · 2023Article
- Risk factors of poor developmental outcome in children with tuberculous meningitis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Structural disconnections associated with language impairments in chronic post-stroke aphasia using disconnectome maps.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Converting sounds to meaning with ventral semantic language networks: integration of interdisciplinary data on brain connectivity, direct electrical stimulation and clinical disconnection syndromes.Brain structure & function · 2022Review
- Tackling the Complexity of Lesion-Symptoms Mapping: How to Bridge the Gap Between Data Scientists and Clinicians?Acta neurochirurgica. Supplement · 2022Article
- Oscillatory beta/alpha band modulations: A potential biomarker of functional language and motor recovery in chronic stroke?Frontiers in human neuroscience · 2022Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The ability to comprehend and produce speech after stroke depends on whether the areas of the brain that support language have been damaged. Here, we review two different ways to predict language outcome after stroke. The first depends on understanding the neural circuits that support language. This model-based approach is a challenging endeavor because language is a complex cognitive function that involves the interaction of many different brain areas. The second approach, by contrast, does not require an understanding of why a lesion impairs language; instead, predictions are made on the basis of the recovery of previous patients with the same lesion. This approach requires a database that records the speech and language capabilities of a large population of patients who have, collectively, incurred a comprehensive range of focal brain lesions. In addition, a system is required that converts an MRI scan from a new patient into a three-dimensional description of the lesion and compares this lesion against all others on the database. The outputs of this system are the longitudinal language outcomes of corresponding patients in the database. This approach will provide the patient with a range of probable recovery patterns over a variety of language measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.