ArticleCirculation2010
Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice.
Article in Circulation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
- Affinity-Enriched Plasma Proteomics for Biomarker Discovery in Abdominal Aortic Aneurysms.Proteomes · 2024Article
- Enhanced complement activation and MAC formation accelerates severe COVID-19.Cellular and molecular life sciences : CMLS · 2024Article
- Emerging role of complement in COVID-19 and other respiratory virus diseases.Cellular and molecular life sciences : CMLS · 2024Review
- Alkaline ceramidase 1-mediated platelet ceramide catabolism mitigates vascular inflammation and abdominal aortic aneurysm formation.Nature cardiovascular research · 2023Article
- Deficiency of Caspase-1 Attenuates HIV-1-Associated Atherogenesis in Mice.International journal of molecular sciences · 2023Article
- Dexmedetomidine protects cells from Angiotensin II-induced smooth muscle cell phenotype switch and endothelial cell dysfunction.Cell cycle (Georgetown, Tex.) · 2023Article
- Statin therapy protects against abdominal aortic aneurysms by inducing the accumulation of regulatory T cells in ApoEJournal of molecular medicine (Berlin, Germany) · 2022Article
- Ageing- and AAA-associated differentially expressed proteins identified by proteomic analysis in mice.PeerJ · 2022Article
- Common molecular mechanism and immune infiltration patterns of thoracic and abdominal aortic aneurysms.Frontiers in immunology · 2022Article
- Identification of a biomarker and immune infiltration in perivascular adipose tissue of abdominal aortic aneurysm.Frontiers in physiology · 2022Article
- HIST1H2BN induced cell proliferation and EMT phenotype in prostate cancer via NF-κB signal pathway.Genes & genomics · 2021Article
- Endothelial cell infection and dysfunction, immune activation in severe COVID-19.Theranostics · 2021Article
- Involvement of Myeloid Cells and Noncoding RNA in Abdominal Aortic Aneurysm Disease.Antioxidants & redox signaling · 2020Review
- Versatile cell ablation tools and their applications to study loss of cell functions.Cellular and molecular life sciences : CMLS · 2019Review
- Regulatory T cells protected against abdominal aortic aneurysm by suppression of the COX-2 expression.Journal of cellular and molecular medicine · 2019Article
- Intracerebral matrix metalloproteinase 9 in fatal diabetic ketoacidosis.Experimental and molecular pathology · 2019Article
- Complement activation in the arteries of patients with severe atherosclerosis.International journal of clinical and experimental pathology · 2018Article
- Deletion of resistin-like molecule-beta attenuates angiotensin II-induced abdominal aortic aneurysm.Oncotarget · 2017Article
- Weighted Gene Co-expression Network Analysis Identifies FKBP11 as a Key Regulator in Acute Aortic Dissection through a NF-kB Dependent Pathway.Frontiers in physiology · 2017Article
- Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundComplement system, an innate immunity, has been well documented to play a critical role in many inflammatory diseases. However, the role of complement in the pathogenesis of abdominal aortic aneurysm, which is considered an immune and inflammatory disease, remains obscure. METHODS AND
resultsHere, we evaluated the pathogenic roles of complement membrane attack complex and CD59, a key regulator that inhibits the membrane attack complex, in the development of abdominal aortic aneurysm. We demonstrated that in the angiotensin II-induced abdominal aortic aneurysm model, deficiency of the membrane attack complex regulator CD59 in ApoE-null mice (mCd59ab(-/-)/ApoE(-/-)) accelerated the disease development, whereas transgenic overexpression of human CD59 (hCD59(ICAM-2+/-)/ApoE(-/-)) in this model attenuated the progression of abdominal aortic aneurysm. The severity of aneurysm among these 3 groups positively correlates with C9 deposition, and/or the activities of MMP2 and MMP9, and/or the levels of phosphorylated c-Jun, c-Fos, IKK-alpha/beta, and p65. Furthermore, we demonstrated that the membrane attack complex directly induced gene expression of matrix metalloproteinase-2 and -9 in vitro, which required activation of the activator protein-1 and nuclear factor-kappaB signaling pathways.
conclusionsTogether, these results defined the protective role of CD59 and shed light on the important pathogenic role of the membrane attack complex in abdominal aortic aneurysm.
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