ArticleProceedings of the National Academy of Sciences of the United States of America2010
Transgenic expression of CBBP, a CXC domain protein, establishes paramutation in maize.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Genome-wide identification and expression pattern analysis of the CPP transcription factor family in Medicago sativa L.BMC plant biology · 2025Article
- Identification of Proteins Associated with Stably Integrated MaizePlants (Basel, Switzerland) · 2025Article
- Comprehensive identification and expression analysis of the CPP gene family in maize (Zea mays L.).BMC plant biology · 2025Article
- Article
- Genome-wide identification and expression analysis ofOpen life sciences · 2022Article
- Chlamydomonas CHT7 Is Required for an Effective Quiescent State by Regulating Nutrient-Responsive Cell Cycle Gene Expression.The Plant cell · 2020Article
- Nitrogen-dependent coordination of cell cycle, quiescence and TAG accumulation in Chlamydomonas.Biotechnology for biofuels · 2019Review
- Exploring the extent and scope of epigenetic inheritance.Nature reviews. Endocrinology · 2018Review
- Trans-Homolog Interactions Facilitating Paramutation in Maize.Plant physiology · 2015Review
- Prolonged expression of the BX1 signature enzyme is associated with a recombination hotspot in the benzoxazinoid gene cluster in Zea mays.Journal of experimental botany · 2015Article
- Involvement of Multiple Gene-Silencing Pathways in a Paramutation-like Phenomenon in Arabidopsis.Cell reports · 2015Article
- Functional diversification of maize RNA polymerase IV and V subtypes via alternative catalytic subunits.Cell reports · 2014Article
- Review
- Noncoding RNA and Polycomb recruitment.RNA (New York, N.Y.) · 2013Review
- Specific tandem repeats are sufficient for paramutation-induced trans-generational silencing.PLoS genetics · 2013Article
- required to maintain repression2 is a novel protein that facilitates locus-specific paramutation in maize.The Plant cell · 2012Article
- Transgenic epigenetics: using transgenic organisms to examine epigenetic phenomena.Genetics research international · 2012Article
- Paramutation: just a curiosity or fine tuning of gene expression in the next generation?Current genomics · 2011Article
- RNA-mediated trans-communication can establish paramutation at the b1 locus in maize.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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4 authors.
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Abstract
Paramutation is the ability of specific DNA sequences to communicate in trans to establish meiotically heritable expression states. Paramutation at the maize b1 locus is mediated by seven unique noncoding transcribed tandem repeats of 853 bp that are required to establish and maintain the meiotically heritable expression and distinct chromatin states associated with b1 paramutation. In this study, we report the identification of a CXC-domain protein CBBP (CXC domain b1-repeat binding protein) that binds to a defined region within the b1 tandem repeat sequence in vivo and in vitro. When CBBP is expressed from a transgene in maize, it can induce a silent state at the b1 locus that is heritable in progeny no longer containing the transgene, and the silent epiallele is capable of silencing an active epiallele, characteristic of paramutation. Accumulation of the CBBP protein correlates with b1 silencing in transgenic and nontransgenic plants. The ability of CBBP to form multimers and to bind to the b1 tandem repeats suggests a model for counting the number of b1 repeats. In contrast to previously identified proteins involved in paramutation, CBBP does not share similarity to the known components of the Arabidopsis RNAi heterochromatin silencing pathway. Thus, this study defines another class of protein that is involved in heritable gene silencing.
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