ArticleMolecular and cellular biology2010
Dominant role for signal transduction in the transcriptional memory of yeast GAL genes.
Article in Molecular and cellular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 67 citations in OpenAlex.
- Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting.Nature structural & molecular biology · 2023Article
- Differential regulation of mRNA stability modulates transcriptional memory and facilitates environmental adaptation.Nature communications · 2023Article
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- Microbial Adaptation to Enhance Stress Tolerance.Frontiers in microbiology · 2022Review
- Protein acetylation regulates xylose metabolism during adaptation of Saccharomyces cerevisiae.Biotechnology for biofuels · 2021Article
- The roles of inducible chromatin and transcriptional memory in cellular defense system responses to redox-active pollutants.Free radical biology & medicine · 2021Review
- Variation, Variegation and Heritable Gene Repression inFrontiers in genetics · 2021Review
- The past determines the future: sugar source history and transcriptional memory.Current genetics · 2020Review
- Capturing and Understanding the Dynamics and Heterogeneity of Gene Expression in the Living Cell.International journal of molecular sciences · 2020Review
- Metabolic transcriptional memory.Molecular metabolism · 2020Review
- On the duration of the microbial lag phase.Current genetics · 2019Review
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- Epigenetic memory in gene regulation and immune response.BMB reports · 2019Review
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- Rpd3L HDAC links H3K4me3 to transcriptional repression memory.Nucleic acids research · 2018Article
- Quantitative imaging of chromatin decompaction in living cells.Molecular biology of the cell · 2018Article
- Assigning function to natural allelic variation via dynamic modeling of gene network induction.Molecular systems biology · 2018Article
- Genetic and Epigenetic Strategies Potentiate Gal4 Activation to Enhance Fitness in Recently Diverged Yeast Species.Current biology : CB · 2017Article
- Epigenetic Transcriptional Memory ofGenetics · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Several recent studies have shown that the transcriptional induction of yeast GAL genes occurs with faster kinetics if the gene has been previously expressed. Depending on the experimental regimen, this transcriptional "memory" phenomenon can persist for 1 to 2 cell divisions in the absence of an inducer (short-term memory) or for >6 cell divisions (long-term memory). Long-term memory requires the GAL1 gene, suggesting that memory involves the cytoplasmic inheritance of high levels of Gal1 that are expressed in the initial round of expression. In contrast, short-term memory requires the SWI/SNF chromatin-remodeling enzyme, and thus, it may involve the inheritance of distinct chromatin states. Here we have reevaluated the roles of SWI/SNF, the histone variant H2A.Z, and components of the nuclear pore in both the short-term and long-term memory of GAL genes. Our results suggest that the propagation of novel chromatin structures does not contribute to the transcriptional memory of GAL genes, but rather, memory of the previous transcription state is controlled primarily by the inheritance of the Gal3p and Gal1p signaling factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.