ArticleThe Journal of physiology2010
Obligatory role of hyperaemia and shear stress in microvascular adaptation to repeated heating in humans.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06932250 (Vascular and Neural Mechanisms of Chronic Leg Heating in Pregnant Women With Obesity), which is not on this map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vascular and Neural Mechanisms of Chronic Leg Heating in Pregnant Women With Obesity
Who cites it
66 citing papers in PubMed, 116 citations in OpenAlex.
- Effects of Alternating Mild-Cold and Hot Water Immersion on Lower-Leg Blood Flow Following Immersion in Healthy Young Adults.Scandinavian journal of medicine & science in sports · 2026Trial
- Low-dose ASA therapy does not alter core or skin temperature during hot-dry or warm-humid heat stress (PSU HEAT project).Physiological reports · 2025Trial
- Leg heat therapy improves perceived physical function but does not enhance walking capacity or vascular function in patients with peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- Effects of supervised exercise training on lower-limb cutaneous microvascular reactivity in adults with venous ulcers.European journal of applied physiology · 2018Trial
- Thermotherapy reduces blood pressure and circulating endothelin-1 concentration and enhances leg blood flow in patients with symptomatic peripheral artery disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Trial
- Acute effects of warm footbath on arterial stiffness in healthy young and older women.European journal of applied physiology · 2012Trial
- Temperature-dependent release of ATP from human erythrocytes: mechanism for the control of local tissue perfusion.Experimental physiology · 2012Trial
- Systemic low-dose aspirin and clopidogrel independently attenuate reflex cutaneous vasodilation in middle-aged humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Trial
- Comparison between exercise and hot water immersion on skin microvascular responses in older adults with overweight and obesity.European journal of applied physiology · 2026Article
- Sex differences in macrovascular responsiveness: Acute effects of hot water immersion versus aerobic exercise in overweight older adults.Experimental physiology · 2026Article
- A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026Review
- Far-infrared sauna exposure at 65°C elevates core temperature.Experimental physiology · 2026Article
- Comparison of exercise training and repeated hot water immersion on vascular function in overweight older adults.Experimental physiology · 2026Article
- Identifying the interaction between skin temperature, maintained thermal comfort, and conduit artery shear rate through limb passive heating.Physiological reports · 2026Article
- Sex differences in dynamic cerebral autoregulation responses to resistance and endurance training in humans.Experimental physiology · 2026Article
- The effect of repeated hot water immersion on microvascular function, glycaemic control and inflammation in White European and South Asian males.Experimental physiology · 2026Article
- Heat Therapy: Targeting Health, Disease, and Disability.Comprehensive Physiology · 2026Review
- Cutaneous microvascular function is reduced in winter compared with summer in healthy young adults.Physiological reports · 2026Article
- Autonomic control of blood pressure in women: The roles of hypertension and aging.Autonomic neuroscience : basic & clinical · 2025Review
- The Synergistic Effect of Heat Therapy and Electroacupuncture Treatment in Inflammatory Pain Mouse Models.Brain sciences · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endothelium, a single layer of cells lining the entire circulatory system, plays a key role in maintaining vascular health. Endothelial dysfunction independently predicts cardiovascular events and improvement in endothelial function is associated with decreased vascular risk. Previous studies have suggested that exercise training improves endothelial function in macrovessels, a benefit mediated via repeated episodic increases in shear stress. However, less is known of the effects of shear stress modulation in microvessels. In the present study we examined the hypothesis that repeated skin heating improves cutaneous microvascular vasodilator function via a shear stress-dependent mechanism. We recruited 10 recreationally active males who underwent bilateral forearm immersion in warm water (42 degrees C), 3 times per week for 30 min. During these immersion sessions, shear stress was manipulated in one arm by inflating a pneumatic cuff to 100 mmHg, whilst the other arm remained uncuffed. Vasodilatation to local heating, a NO-dependent response assessed using laser Doppler, improved across the 8 week intervention period in the uncuffed arm (cutaneous vascular conductance week 0 vs. week 4 at 41 degrees C: 1.37 +/- 0.45 vs. 2.0 +/- 0.91 units, P = 0.04; 42 degrees C: 2.06 +/- 0.45 vs. 2.68 +/- 0.83 units; P = 0.04), whereas no significant changes were evident in the cuffed arm. We conclude that increased blood flow, and the likely attendant increase in shear stress, is a key physiological stimulus for enhancing microvascular vasodilator function in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.