ArticleThe Journal of physiology2010
Characterisation of bipolar cell synaptic transmission in goldfish retina using paired recordings.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- The role of syntaxins in retinal function and health.Frontiers in cellular neuroscience · 2024Review
- Functional maturation of the rod bipolar to AII-amacrine cell ribbon synapse in the mouse retina.Cell reports · 2023Article
- A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina.Nature communications · 2023Article
- Two Pools of Vesicles Associated with Synaptic Ribbons Are Molecularly Prepared for Release.Biophysical journal · 2017Article
- Postsynaptic Plasticity Triggered by Ca²⁺-Permeable AMPA Receptor Activation in Retinal Amacrine Cells.Neuron · 2016Article
- Calcium spike-mediated digital signaling increases glutamate output at the visual threshold of retinal bipolar cells.Journal of neurophysiology · 2015Article
- Nitric oxide mediates activity-dependent plasticity of retinal bipolar cell output via S-nitrosylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Amperometric resolution of a prespike stammer and evoked phases of fast release from retinal bipolar cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Alert response to motion onset in the retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Light-evoked lateral GABAergic inhibition at single bipolar cell synaptic terminals is driven by distinct retinal microcircuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The diverse roles of ribbon synapses in sensory neurotransmission.Nature reviews. Neuroscience · 2010Review
- Extending the realm of membrane capacitance measurements to nerve terminals with complex morphologies.The Journal of physiology · 2010Article
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Abstract
Direct recordings from the large axon terminals of goldfish retinal bipolar cells (BCs) have revealed detailed information about the properties and regulation of exocytosis at this ribbon-type synapse. However, the relationship between BC exocytosis and evoked postsynaptic responses in amacrine and ganglion cells is not known. To address this, I have made paired recordings from BC terminals (BCTs) and neurons in the ganglion cell layer (GCL) in goldfish retinal slices. BCT depolarisation evoked short-latency, AMPA/kainate receptor-mediated EPSCs in connected GCL neurons. NMDA receptors contributed to the response at +40 mV but not at 60 mV. Evoked EPSCs contained multiple temporal components that differed in their relative amplitudes between pairs. Changing the duration or amplitude of the presynaptic stimulus affected the size and kinetics of the EPSC, with weaker stimuli slowing the EPSC activation rate. Paired-pulse stimulation caused greater depression of fast than slow EPSC components. A linear relationship was found between the amount of BCT exocytosis, measured via changes in membrane capacitance, and the charge of evoked EPSCs, whether they were mediated by AMPA/kainate receptors alone or in combination with NMDA receptors. In addition, analysis of miniature EPSCs in GCL neurons provided estimates of the quantal content of evoked EPSCs. The results demonstrate the feasibility of using this paired recording system to study synaptic transfer at ribbon synapses, and indicate that both the rapid and sustained phases of BC exocytosis are encoded in the postsynaptic response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.