ArticleJournal of lipid research2010
Lower HDL-C and apolipoprotein A-I are related to higher glomerular filtration rate in subjects without kidney disease.
Article in Journal of lipid research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Higher Free Triiodothyronine Is Associated With Higher HDL Particle Concentration and Smaller HDL Particle Size.The Journal of clinical endocrinology and metabolism · 2022Article
- The Effects of Cardiometabolic Factors on the Association Between Serum Uric Acid and Chronic Kidney Disease in Chinese Middle-Aged and Older Population: A Mediation Analysis.Frontiers in endocrinology · 2021Article
- Temporal Dynamics of High-Density Lipoprotein Proteome in Diet-Controlled Subjects with Type 2 Diabetes.Biomolecules · 2020Article
- The association between high-density lipoproteins and estimated glomerular filtration rate in patients without severe kidney disease.International urology and nephrology · 2018Article
- Effect of high density lipoprotein cholesterol on the relationship of serum iron and hemoglobin with kidney function in diabetes.Journal of diabetes and its complications · 2017Article
- Dietary Strategies and Novel Pharmaceutical Approaches Targeting Serum ApoA-I Metabolism: A Systematic Overview.Journal of nutrition and metabolism · 2017Review
- In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models.JACC. Cardiovascular imaging · 2016Article
- PET Imaging of Tumor-Associated Macrophages with 89Zr-Labeled High-Density Lipoprotein Nanoparticles.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015Article
- APOL1 G1 genotype modifies the association between HDLC and kidney function in African Americans.BMC genomics · 2015Article
- Arginine-directed glycation and decreased HDL plasma concentration and functionality.Nutrition & diabetes · 2014Article
- Age, kidney function, and risk factors associate differently with cortical and medullary volumes of the kidney.Kidney international · 2014Article
- Relationship of ghrelin, acid uric and proinflammatory adipocytokines in different degrees of obesity or diabetes.International journal of clinical and experimental medicine · 2014Article
- Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association.International journal of nephrology · 2012Article
- High-density lipoprotein cholesterol and causes of death in chronic kidney disease.Journal of clinical lipidologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal experiments show that the kidney contributes to apolipoprotein (apo)A-I catabolism. We tested relationships of HDL cholesterol (HDL-C) and apo-I with kidney function in subjects without severe chronic kidney disease. Included was a random sample of the general population (part of the PREVEND cohort). Kidney function [estimated glomerular filtration rate (e-GFR) by two well-established equations and creatinine clearance], HDL-C, triglycerides, apoA-I and insulin resistance (HOMAir) were measured in 2,484 fasting subjects (e-GFR>or=45 ml/min/1.73 m2) without macroalbuminuria, cardiovascular disease, diabetes, or the use of anti-hypertensives and/or lipid-lowering agents. HDL-C (r=-0.056 to -0.102, P<0.01 to <0.001) and apo A-I (r=-0.096 to -0.126, P<0.001) were correlated inversely with both GFR estimates and creatinine clearance in univariate analyses. Multiple linear regression analyses also demonstrated inverse relationships of HDL-C and apoA-I with all measures of kidney function even after adjustment for age, sex, waist circumference, HOMAir, triglycerides, and urinary albumin excretion (P=0.053 to 0.004). In conclusion, HDL-C and apoA-I are inversely related to e-GFR and creatinine clearance in subjects without severely compromised kidney function, which fits the concept that the kidney contributes to apoA-I regulation in humans. High glomerular filtration rate may be an independent determinant of a pro-atherogenic lipoprotein profile.
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