ArticleAntimicrobial agents and chemotherapy2010
Differentiation of clonal complex 59 community-associated methicillin-resistant Staphylococcus aureus in Western Australia.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed.
- Global emergence and evolution ofmSystems · 2026Article
- Virulence attributes of successful methicillin-resistantClinical microbiology reviews · 2023Review
- Resistance and Molecular Characteristics of Methicillin-ResistantInfection and drug resistance · 2023Article
- Whole genome sequencing reveals new links between spa t172/CC59 methicillin-resistant Staphylococcus aureus cases in low-endemicity region of Southwest Finland, 2007‒2016.Scientific reports · 2022Article
- Article
- Diversity of bacteriophages encoding Panton-Valentine leukocidin in temporally and geographically related Staphylococcus aureus.PloS one · 2020Article
- Molecular Characterization of Methicillin- Resistant Staphylococcus aureus in a Tertiary Care hospital in Kuwait.Scientific reports · 2019Article
- Molecular typing revealed the emergence ofInfection and drug resistance · 2019Article
- Prevalence and Characterization of Food-Related Methicillin-ResistantFrontiers in microbiology · 2019Article
- Molecular characteristics of Staphylococcus aureus isolates from food surveillance in southwest China.BMC microbiology · 2018Article
- Population structure and virulence gene profiles of Streptococcus agalactiae collected from different hosts worldwide.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Article
- Distribution of the Most PrevalentFrontiers in microbiology · 2018Review
- Novel Structure of Enterococcus faecium-Originated ermB-Positive Tn1546-Like Element in Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2016Article
- Identification of source and sink populations for the emergence and global spread of the East-Asia clone of community-associated MRSA.Genome biology · 2016Article
- Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Isolated from Australian Veterinarians.PloS one · 2016Article
- Article
- Potential Relationship between Phenotypic and Molecular Characteristics in Revealing Livestock-AssociatedFrontiers in microbiology · 2016Article
- Article
- Genetic and molecular predictors of high vancomycin MIC in Staphylococcus aureus bacteremia isolates.Journal of clinical microbiology · 2014Article
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Authors and funding
8 authors.
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Abstract
Clonal complex 59 (CC59) community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains were characterized using pulsed-field gel electrophoresis, spa typing, multilocus sequence typing, diagnostic DNA microarrays, and PCRs targeting staphylococcal cassette chromosome mec (SCCmec) elements and Panton-Valentine leukocidin (PVL). Six distinct groups within CC59 were characterized. At least seven different variants of SCCmec elements were identified (IVa [2B], IVb [2B], IVd [2B], IV variant [2B], IVa [2B&5], V variant [5C2], and V [5C2&5]). (The structural type is indicated by a Roman numeral, with a lowercase letter indicating the subtype, and the ccr complex and the mec complex are indicated by an Arabic numeral and an uppercase letter, respectively. Where there is an extra ccr element, this is indicated by "&" and an Arabic numeral designating the ccr type.) The first group is similar to the American sequence type 59 (ST59) MRSA-IV CA-MRSA strain USA1000. The second group includes a PVL-negative ST87 strain with an SCCmec element of subtype IVb (2B). The third group comprises PVL-variable ST59 MRSA-IV strains harboring multiple SCCmec IV subtypes. PVL-negative ST59 MRSA strains with multiple or composite SCCmec elements (IVa [2B&5]) form the fourth group. Group 5 corresponds to the internationally known "Taiwan clone," a PVL-positive strain with a variant SCCmec element (V [5C2&5]). This strain proved to be the most common CC59 MRSA strain isolated in Western Australia. Finally, group 6 encompasses the ST59 MRSA-V variant (5C2). The differentiation of CC59 into groups and strains indicates a rapid evolution and spread of SCCmec elements. Observed differences between groups of strains as well as intrastrain variability within a group facilitate the tracing of their spread.
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