Evidence map›Paper›PMID 20211749›Full record

ReviewSeminars in cell & developmental biology2010

A view from Drosophila: multiple biological functions for individual microRNAs.

Peter Smibert, Eric C Lai

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. First Report ofInsects · 2020
    Article
  4. Article
  5. Article
  6. TheDevelopment (Cambridge, England) · 2018
    Article
  7. Article
  8. Article
  9. Article
  10. Genome-Wide Profiling ofFrontiers in physiology · 2017
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Adult-specific functions of animal microRNAs.Nature reviews. Genetics · 2013
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Peter SmibertDepartment of Developmental Biology, Sloan-Kettering Institute, 1275 York Ave, Box 252, New York, NY 10065, USA.
Eric C Lai

Funding

Selective regulatory and biogenesis mechanisms for microRNAsR01GM083300 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Eric C Lai · 2007 to 2026
$9.8M
Annotation of the small RNA/microRNA component Drosophila genomeU01HG004261 · NHGRI · SLOAN-KETTERING INST CAN RESEARCH · PI LAI, ERIC C · 2007 to 2011
$2.5M
NHGRI NIH HHS U01 HG004261NHGRI NIH HHS U01-HG004261NIGMS NIH HHS R01 GM083300NIGMS NIH HHS R01-GM083300
6 · The paper itself

Abstract

microRNAs (miRNAs) comprise an extensive class of post-transcriptional regulatory molecules in higher eukaryotes. Intensive research in Drosophila has revealed that miRNAs control myriad developmental and physiological processes. Interestingly, several of the best-studied miRNAs impact multiple biological processes, often by regulating distinct key target genes in each setting. Here we discuss the roles of some of these pleiotropic miRNAs, and their implications for studying and interpreting the roles of miRNAs in gene regulatory networks.

Indexed as

AnimalsDrosophilaGene Regulatory NetworksGenetic PleiotropyMicroRNAsMicroRNAs

Identifiers

PMID20211749
PMCPMC2919623

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.