ArticlePharmacology, biochemistry, and behavior2010
Preadolescent tobacco smoke exposure leads to acute nicotine dependence but does not affect the rewarding effects of nicotine or nicotine withdrawal in adulthood in rats.
Article in Pharmacology, biochemistry, and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Dissociable roles of dopamine D1 and nicotinic receptors in nicotine-motivated responding and impulsive action in a Go/No-Go self-administration task.bioRxiv : the preprint server for biology · 2026Article
- The role of glucocorticoid and nicotinic acetylcholine receptors in the reward-enhancing effects of nicotine in the ICSS procedure in male and female rats.Drug and alcohol dependence · 2025Article
- Effectiveness of Juniper Essential Oils in Reducing Selected Cigarette Smoke Toxicants, Improving Oxidative Parameters, and Cytotoxicity Against Lung Adenocarcinoma.Biochemistry research international · 2025Article
- Flavokavains A- and B-Free Kava Enhances Resilience against the Adverse Health Effects of Tobacco Smoke in Mice.ACS pharmacology & translational science · 2024Article
- Sex differences in nicotine intake and relapse behavior in nicotine-dependent adult wistar rats.Frontiers in pharmacology · 2024Article
- Chronic exposure to cigarette smoke extract increases nicotine withdrawal symptoms in adult and adolescent male rats.Advances in drug and alcohol research · 2023Article
- Tobacco smoke exposure enhances reward sensitivity in male and female rats.Psychopharmacology · 2021Article
- Adolescent nicotine and tobacco smoke exposure enhances nicotine self-administration in female rats.Neuropharmacology · 2020Article
- Exposure to smoke from high- but not low-nicotine cigarettes leads to signs of dependence in male rats and potentiates the effects of nicotine in female rats.Pharmacology, biochemistry, and behavior · 2020Article
- Effects of environmental tobacco smoke exposure on brain functioning in never-smoking adolescents.Brain and behavior · 2020Article
- Enhancing effects of acute exposure to cannabis smoke on working memory performance.Neurobiology of learning and memory · 2019Article
- Impact of Electronic Cigarettes on the Cardiovascular System.Journal of the American Heart Association · 2017Review
- Delivery of nicotine aerosol to mice via a modified electronic cigarette device.Drug and alcohol dependence · 2017Article
- Article
- Parental smoke exposure and the development of nicotine craving in adolescent novice smokers: the roles of DRD2, DRD4, and OPRM1 genotypes.BMC pulmonary medicine · 2015Article
- Nicotine-Cadmium Interaction Alters Exploratory Motor Function and Increased Anxiety in Adult Male Mice.Journal of neurodegenerative diseases · 2014Article
- Predictors of nicotine dependence symptoms among never-smoking adolescents: a longitudinal analysis from the Nicotine Dependence in Teens Study.Drug and alcohol dependence · 2013Article
- Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking.Frontiers in psychiatry · 2013Article
- Reward sensitization: effects of repeated nicotine exposure and withdrawal in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- A rat model of cigarette smoke abuse liability.Comparative medicine · 2012Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Epidemiological studies indicate that parental smoking increases the risk for smoking in children. However, the underlying mechanisms by which parental smoking increases the risk for smoking are not known. The aim of these studies was to investigate if preadolescent tobacco smoke exposure, postnatal days 21-35, affects the rewarding effects of nicotine and nicotine withdrawal in adult rats. The rewarding effects of nicotine were investigated with the conditioned place preference procedure. Nicotine withdrawal was investigated with the conditioned place aversion procedure and intracranial self-stimulation (ICSS). Elevations in brain reward thresholds in the ICSS paradigm reflect a dysphoric state. Plasma nicotine and cotinine levels in the preadolescent rats immediately after smoke exposure were 188 ng/ml and 716 ng/ml, respectively. Preadolescent tobacco smoke exposure led to the development of nicotine dependence as indicated by an increased number of mecamylamine-precipitated somatic withdrawal signs in the preadolescent tobacco smoke exposed rats compared to the control rats. Nicotine induced a similar place preference in adult rats that had been exposed to tobacco smoke or air during preadolescence. Furthermore, mecamylamine induced place aversion in nicotine dependent rats but there was no effect of preadolescent tobacco smoke exposure. Finally, preadolescent tobacco smoke exposure did not affect the elevations in brain reward thresholds associated with precipitated or spontaneous nicotine withdrawal. These studies indicate that passive exposure to tobacco smoke during preadolescence leads to the development of nicotine dependence but preadolescent tobacco smoke exposure does not seem to affect the rewarding effects of nicotine or nicotine withdrawal in adulthood.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.